Nickel(II) acetylacetonate for the first time was shown to efficiently catalyze the addition of Boc-protected amino acid hydrazides to the nitrile group of benzoylcyanamide with the formation of the corresponding 3-benzoylamino-substituted 1,2,4-triazoles with the Boc-aminoalkyl group at position 5. A further modification of the latter led, depending on the conditions, to mono- or dihydrochlorides of 1,2,4-triazole-derived amines.

中文翻译：

---

一种合成 3-氨基和 3-苯甲酰氨基-5-氨基烷基-1,2,4-三唑的新方法

乙酰丙酮镍 (II) 首次被证明可以有效地催化 Boc 保护的氨基酸酰肼加成到苯甲酰氰胺的腈基上，并与 Boc 形成相应的 3-苯甲酰氨基取代的 1,2,4-三唑-氨基烷基在5位。根据条件，后者的进一步修饰导致1,2,4-三唑衍生的胺的单盐酸盐或二盐酸盐。