Maxacalcitol (1), a kind of active vitamin D drugs, was prepared from pregnenolone acetate (2) using a novel synthetic method including the combination of five-step organic transformations and one-step biological transformation. The new protocol was shorter, milder, and simpler than the reported approaches. The unoptimized overall yield was 0.178%. The structure of all intermediates and final product was confirmed by ¹H NMR, ¹³C NMR and MS techniques.

中文翻译：

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合成马沙骨化醇的新方法

马沙骨化醇（1），一种活性的维生素d药物，由孕烯醇酮乙酸酯（制备2使用新的合成方法，包括五步有机转化和一步生物转化的组合）。新协议比已报道的方法更短，更温和，更简单。未优化的总产率为0.178％。所有中间体和最终产物的结构通过¹ H NMR，¹³ C NMR和MS技术确认。