Rapid alkylations of thiols are performed in a packed-bed flow reactor where potassium carbonate acts as a heterogeneous base in anhydrous solvents at ambient temperature. The reaction also has a high efficiency as the removal of the solvent is the only work up required to isolate the product. The products can be used in a subsequent oxidation which was performed sequentially in semibatch mode. The alkylations of phenol and benzyl amine have been demonstrated on an array of bases, but higher temperatures and longer reaction times are required than with thiols.

中文翻译：

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在填充床反应器中使用异质碱进行硫醇，苯酚和胺的流烷基化

硫醇的快速烷基化反应在填充床流动反应器中进行，其中碳酸钾在环境温度下在无水溶剂中充当多相碱。该反应还具有高效率，因为除去溶剂是分离产物所需的唯一后处理。产物可用于随后的氧化中，该氧化以半间歇模式顺序进行。苯酚和苄胺的烷基化已在一系列碱中得到证实，但与硫醇相比，需要更高的温度和更长的反应时间。