Previously unknown 3′-R¹-spiro[(aza/oxa/thia)cycloalkyl-1(3, 4),6′-[1,2,4]triazino[2,3-c]quinazolin]-2′(7′H)-ones were obtained on the basis of (5+1) cyclocondensation reaction of substituted 6-R¹-3-(2-aminophenyl)-1,2,4-triazin-5(2Н)-ones with cyclic ketones. It was established that the steric and electronic factors of cyclic ketones did not affect the reaction duration and product yields. The structure of the synthesized compounds was proved by ¹Н and ¹³C NMR spectroscopy, mass spectrometry, and X-ray structural analysis. The synthesized compounds were characterized as promising anticonvulsants.

中文翻译：

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[1,2,4]三嗪并[2,3-с]喹唑啉2 *。新型3'-R 1-螺[[氮杂/氧杂/硫杂]环烷基-1（3，4），6'-[1,2,4]三嗪[2,3-c]的合成，结构及抗惊厥活性]喹唑啉] -2′（7′H）-ones

以前未知的3'-R ^1-螺[[氮杂/氧杂/硫杂]环烷基-1（3，4），6'-[1,2,4]三嗪[2,3- c ]喹唑啉] -2'（ 7' ħ的（5 + 1）取代的6-R的环化缩合反应的基础上获得） -酮¹ -3-（2-氨基苯基）-1,2,4-三嗪-5-（2 Н带） -酮环状酮。已经确定，环状酮的空间和电子因素不影响反应持续时间和产物产率。合成的化合物的结构通过证明¹ Н和¹³ C NMR光谱法，质谱法，和X射线结构分析。合成的化合物被表征为有前途的抗惊厥药。