A new one-pot method for the synthesis of 2,3,4,6,7,8,9,10-octahydro-1H-pyrazino[1,2-a]quinolines was developed based on a three-component reaction between methyl (3-oxopiperazin-2-ylidene)acetate, aromatic aldehydes, and cyclohexane-1,3-diones. It was shown by HPLC-MS analysis that this cascade reaction involved a sequence of steps including condensation between 1,3-diketone and aldehyde, addition of heterocyclic enaminone as a C-nucleophile, and intramolecular heterocyclization.

中文翻译：

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新型多组分合成吡嗪并[1,2-a]喹啉的新方法

基于三组分反应，建立了 一种新的一锅法合成2,3,4,6,7,8,9,10-八氢-1 H-吡嗪并[1,2- a ]喹啉。 （3-氧代哌嗪-2-亚基）乙酸甲酯，芳族醛和环己烷-1,3-二酮。通过HPLC-MS分析表明，该级联反应涉及一系列步骤，包括1，3-二酮和醛之间的缩合，作为C-亲核体的杂环烯胺酮的添加以及分子​​内杂环化。