二月桂酰氨基谷氨酰胺赖氨酸钠（一种新型的基于肽的双子表面活性剂）纳米乳化神经酰胺-2,Journal of Surfactants and Detergents

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二月桂酰氨基谷氨酰胺赖氨酸钠（一种新型的基于肽的双子表面活性剂）纳米乳化神经酰胺-2
Journal of Surfactants and Detergents ( IF 1.6 ) Pub Date : 2016-05-18 , DOI: 10.1007/s11743-016-1819-6
Yonghong Tian ₁ , Yiguang Guo ₂ , Xuefang Yang ₁ , Wanping Zhang ₁

Affiliation

一种新型的基于肽的双子表面活性剂，即二月桂酰氨基谷氨酰胺赖氨酸钠（DLGL）被用于制造稳定的纳米乳剂体系，用于输送疏水性生物活性神经酰胺2分子。通过关注DLGL和神经酰胺2分子之间的相互作用，研究了纳米乳液的相性质，形态和稳定性。通过X射线衍射，差示扫描量热法和傅里叶变换红外光谱对DLGL和神经酰胺2的混合物的相性质进行研究，发现由于DLGL的存在，神经酰胺2的结晶度显着降低。用扫描电镜和透射电镜对DLGL乳化的纳米乳的球形和纳米尺寸进行了表征。使用DLGL制备的纳米乳液即使在50°C下保存一个月后，也显示出分散稳定性的显着改善，而粒径没有任何显着变化。结果表明，DLGL容易与神经酰胺-2结合形成相对稳定的结构。DLGL的空间位阻以及DLGL和神经酰胺2的分子重排归因于神经酰胺2分子组装连续性的中断，这阻碍了其结晶性。

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Nanoemulsification of Ceramide‐2 by Sodium Dilauramidoglutamide Lysine, a Novel Peptide‐Based Gemini Surfactant

A novel peptide‐based gemini surfactant, namely, sodium dilauramidoglutamide lysine (DLGL) was employed to fabricate a stable nanoemulsion system for the delivery of hydrophobic bioactive ceramide‐2 molecules. The phase properties and morphology and stability of the nanoemulsion were investigated by focusing on the interaction between DLGL and ceramide‐2 molecules. The investigation of the phase properties of the mixture of DLGL and ceramide‐2 by X‐ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy revealed remarkable reduction in the crystallinity of ceramide‐2 due to the presence of DLGL. The spherical shape and nanometer size of nanoemulsions emulsified by DLGL were characterized by scanning electron microscopy and transmission electron microscopy. The nanoemulsions prepared using DLGL exhibited significant improvement in the dispersion stability without any significant changes in the particle sizes even after storing them for a month at 50 °C. The results indicated that DLGL readily associated with ceramide‐2 to form a relatively stable structure. The steric hindrance of DLGL and molecular rearrangement of DLGL and ceramide‐2 attributed to a break in the continuity of the molecular assembly of ceramide‐2, which hampered its crystallinity.

更新日期：2016-05-18

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