Abstract

A series of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine substituted sulfonamide and urea derivatives has been synthesized and characterized using spectral techniques. The antiviral activity of these compounds against an avian paramyxo virus (AMPV-1) was screened using MTT assay and found that one of the sulfonamide derivatives (2d) show three-fold higher antiviral activity than Ribavirin, a commercial antiviral drug substance.

Graphical abstract

中文翻译：

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4-（7,7-二甲基-4-（哌嗪-1-基）-5,6,7,8-四氢喹唑啉-2-基）吗啉衍生物的合成及抗病毒研究

摘要

合成了一系列4-（7,7-二甲基-4-（哌嗪-1-基）-5,6,7,8-四氢喹唑啉-2-基）吗啉取代的磺酰胺和脲衍生物，并使用光谱技术对其进行了表征。 。使用MTT分析法筛选了这些化合物对禽副粘病毒（AMPV-1）的抗病毒活性，发现其中一种磺酰胺衍生物（2d）的抗病毒活性比商品抗病毒药物Ribavirin高三倍。

图形概要