Computational fluid dynamics of blood flow in an idealized left human heart,International Journal for Numerical Methods in Biomedical Engineering

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Computational fluid dynamics of blood flow in an idealized left human heart
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2019-12-09 , DOI: 10.1002/cnm.3287
Luca Dedè ₁ , Filippo Menghini ₂ , Alfio Quarteroni _{1,

3}

Affiliation

We construct an idealized computational model of the left human heart for the study of the blood flow dynamics in the left atrium and ventricle. We solve the Navier-Stokes equations in the ALE formulation and we prescribe the left heart wall displacement based on physiological data; moreover, we consider the presence of both the mitral and aortic valves through the resistive method. We simulate the left heart hemodynamics by means of the finite element method and we consider the variational multiscale large eddy simulation (LES) formulation to account for the transitional and nearly turbulent regimes of the blood flow in physiological conditions. The main contribution of this paper is the characterization of the blood flow in an idealized configuration of the left heart aiming at reproducing function in normal conditions. Our assessment is based on the analysis of instantaneous and phase averaged velocity fields, blood pressure, and other clinically meaningful fluid dynamics indicators. Finally, we show that our idealized computational model can be suitably used to study and critically discuss pathological scenarios like that of a regurgitant mitral valve.

中文翻译：

理想化左心血流的计算流体动力学

我们构建了一个理想化的左心计算模型，用于研究左心房和心室的血流动力学。我们求解 ALE 公式中的 Navier-Stokes 方程，并根据生理数据规定左心壁位移；此外，我们通过电阻法考虑二尖瓣和主动脉瓣的存在。我们通过有限元方法模拟左心血流动力学，并考虑变分多尺度大涡模拟 (LES) 公式来解释生理条件下血流的过渡和近湍流状态。本文的主要贡献是描述了左心理想化配置中的血流特征，目的是在正常条件下再现功能。我们的评估基于对瞬时和相位平均速度场、血压和其他具有临床意义的流体动力学指标的分析。最后，我们表明，我们的理想化计算模型可适用于研究和批判性讨论病理情况，如反流二尖瓣的情况。

更新日期：2019-12-09

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