A new series of pyridazin-3-one derivatives were designed, synthesized and evaluated for their preclinical antidepressant effect on Swiss mice. Among the series, compounds 6c, 6d and 6f exhibited significant activity profile in forced swimming test. Compounds 6c and 6d were most efficacious, which at dose of 50 mg kg⁻¹ reduced the time of immobility by 42.85 and 38.09 %, respectively, as compared to the standard drug fluoxetine which reduced the immobility time by 45.23 % at the dose of 32 mg kg⁻¹. All the test and standard compounds were administered orally 60 min before the test. Interestingly, all active compounds did not cause any significant alteration of locomotor activity in mice as compared to control, indicating that the hybrids did not produce any motor impairment effects. The results indicate that pyridazin-3(2H)-one derivatives may have potential therapeutic value for the management of mental depression.

中文翻译：

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5-（苯并[b]呋喃-2-基甲基）-6-甲基哒嗪-3（2H）-一衍生物的合成及抗抑郁活性

设计，合成和评估了一系列新的哒嗪-3-酮衍生物对瑞士小鼠的临床前抗抑郁作用。在该系列中，化合物6c，6d和6f在强迫游泳试验中表现出明显的活性。化合物6c和6d最有效，与标准药物氟西汀相比，在剂量为50 mg kg ^-1时，固定时间减少42.85和38.09％，与标准药物氟西汀在32剂量下，固定时间减少45.23％。毫克公斤^-1。在测试前60分钟口服所有测试化合物和标准化合物。有趣的是，与对照相比，所有活性化合物均未引起小鼠运动能力的任何显着改变，表明该杂种没有产生任何运动损伤作用。结果表明哒嗪-3（2H）一衍生物可能对精神抑郁症的治疗具有潜在的治疗价值。