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Facile Preparation of Cu2Se Nanosheets as Dual-Functional Antibacterial Agents
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-02-14 , DOI: 10.1021/acsabm.9b01084 Yuhuan Zhao 1 , Xianwen Wang 1 , Feng Gao 2 , Chenya Wang 1 , Zongjin Yang 1 , Hanfei Wu 1 , Chunyan Li 3 , Liang Cheng 1 , Rui Peng 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-02-14 , DOI: 10.1021/acsabm.9b01084 Yuhuan Zhao 1 , Xianwen Wang 1 , Feng Gao 2 , Chenya Wang 1 , Zongjin Yang 1 , Hanfei Wu 1 , Chunyan Li 3 , Liang Cheng 1 , Rui Peng 1
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The spread of antibiotic-resistance poses a great threat, making it a growing need to develop other antibacterial strategies and therapeutics. Recently, owing to their excellent physicochemical properties, copper chalcogenides have received extensive attention as photothermal agents. However, most reports are focused on Cu2–xS nanoparticles, whereas very few water-dispersible Cu2–xSe nanomaterials have been reported due to their difficult preparation process. Herein, water-dispersible and biocompatible cuprous selenide nanosheets (Cu2Se NSs) were synthesized by a simple anion exchange method starting from cuprous oxide nanorods (Cu2O NRs), which could also help avoid any environmental pollution caused by the organic solvent used during synthesis. The obtained Cu2Se NSs showed strong absorption in the second near-infrared window (NIR II) with a good photothermal conversion efficiency as high as ∼61.16%, outstanding among the previously reported NIR II photothermal agents. Interestingly, using Staphylococcus aureus and Escherichia coli as model pathogens, these Cu2Se NSs possess an intrinsic bacteriostatic effect and could inhibit the growth of both bacteria species. Furthermore, both the fluorescent-based microscopy and the bacterial morphology analysis using a scanning electron microscope have demonstrated that incubation of both species of bacteria with Cu2Se NSs under laser irradiation (1064 nm) would lead to complete disruption of the bacterial cell wall. Our work presents a facile method to prepare water-dispersible Cu2Se NSs-, which could serve as highly efficient dual-functional antibacterial agents.
中文翻译：
Cu2Se纳米片作为双功能抗菌剂的简便制备
抗生素耐药性的传播构成了巨大威胁，因此越来越需要开发其他抗菌策略和治疗方法。近年来，由于其优异的物理化学性质，铜硫属化物作为光热剂受到了广泛关注。然而，大多数报道都集中在Cu 2- x S 纳米粒子上，而水分散性Cu 2- x Se 纳米材料由于制备过程困难而很少被报道。在此，通过简单的阴离子交换法，从氧化亚铜纳米棒（Cu 2O NRs），这也有助于避免由合成过程中使用的有机溶剂造成的任何环境污染。获得的 Cu 2 Se NSs 在第二近红外窗口 (NIR II) 显示出强烈的吸收，具有高达 61.16% 的良好光热转换效率，在先前报道的 NIR II 光热剂中表现出色。有趣的是，使用金黄色葡萄球菌和大肠杆菌作为模型病原体，这些 Cu 2 Se NSs 具有内在的抑菌作用，可以抑制这两种细菌的生长。此外，基于荧光的显微镜和使用扫描电子显微镜的细菌形态分析都表明，两种细菌与 Cu2 Se NSs 在激光照射（1064 nm）下会导致细菌细胞壁的完全破坏。我们的工作提出了一种制备水分散性 Cu 2 Se NSs- 的简便方法，该方法可用作高效的双功能抗菌剂。
更新日期：2020-02-14
中文翻译：
Cu2Se纳米片作为双功能抗菌剂的简便制备
抗生素耐药性的传播构成了巨大威胁，因此越来越需要开发其他抗菌策略和治疗方法。近年来，由于其优异的物理化学性质，铜硫属化物作为光热剂受到了广泛关注。然而，大多数报道都集中在Cu 2- x S 纳米粒子上，而水分散性Cu 2- x Se 纳米材料由于制备过程困难而很少被报道。在此，通过简单的阴离子交换法，从氧化亚铜纳米棒（Cu 2O NRs），这也有助于避免由合成过程中使用的有机溶剂造成的任何环境污染。获得的 Cu 2 Se NSs 在第二近红外窗口 (NIR II) 显示出强烈的吸收，具有高达 61.16% 的良好光热转换效率，在先前报道的 NIR II 光热剂中表现出色。有趣的是，使用金黄色葡萄球菌和大肠杆菌作为模型病原体，这些 Cu 2 Se NSs 具有内在的抑菌作用，可以抑制这两种细菌的生长。此外，基于荧光的显微镜和使用扫描电子显微镜的细菌形态分析都表明，两种细菌与 Cu2 Se NSs 在激光照射（1064 nm）下会导致细菌细胞壁的完全破坏。我们的工作提出了一种制备水分散性 Cu 2 Se NSs- 的简便方法，该方法可用作高效的双功能抗菌剂。
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