Pluronic F127对聚（N-异丙基丙烯酰胺-丙烯酸）水凝胶的3D孔形态及其从S-亚硝基谷胱甘肽中释放一氧化氮的影响,Journal of Applied Polymer Science

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Pluronic F127对聚（N-异丙基丙烯酰胺-丙烯酸）水凝胶的3D孔形态及其从S-亚硝基谷胱甘肽中释放一氧化氮的影响
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-02-04 , DOI: 10.1002/app.49056
Flávia Mesquita Cabrini ₁ , Mathilde Champeau ₂ , Marcelo Ganzarolli Oliveira ₁

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改变水凝胶的孔形态可以是调节其药物释放曲线的有效策略。这里，普朗尼克F127被用于改变交联的聚的三维孔结构（Ñ -isopropylacrylamide-共-丙烯酸）（P [NIPAm-共-AAc]）的水凝胶。F127分别在8和30°C合成的水凝胶中将孔径从20±4减小到2.9±0.4μm，从11±1减小到1.4±0.4μm。X射线小角度散射表明，聚合过程中F127的偏析诱导F127从单聚体（在8°C下）或立方堆积的胶束（在30°C下）到层状结构的相变。P（NIPAm-合作带有S-亚硝基谷胱甘肽（GSNO）的-AAc）水凝胶在水合过程中会自发释放一氧化氮（NO）。孔径的减小导致水凝胶的吸水率增加两倍至三倍，而水凝胶的NO释放速率则增加四倍至六倍。F127可以被用于改变P（NIPAm-的孔形态共-AAc）水凝胶，在其水合作用和由GSNO NO释放速率伴随变化，打开一个新的透视它们在局部递送NO使用。

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Effect of Pluronic F127 on the 3D pore morphology of poly(N‐isopropylacrylamide‐co‐acrylic acid) hydrogels and their nitric oxide release from S‐nitrosoglutathione

Changing the pore morphology of hydrogels can be an effective strategy to modulate their drug release profiles. Herein, Pluronic F127 was used to change the three‐dimensional pore morphology of crosslinked poly(N ‐isopropylacrylamide‐co ‐acrylic acid) (P[NIPAm‐co ‐AAc]) hydrogels. F127 reduced the pore diameters from 20 ± 4 to 2.9 ± 0.4 μm and from 11 ± 1 to 1.4 ± 0.4 μm in hydrogels synthesized at 8 and 30°C, respectively. Small‐angle X‐ray scattering indicates that the segregation of the F127 during the polymerization process induces F127 phase transitions from unimers (at 8°C) or cubic‐packed micelles (at 30°C) to a lamellar structure. P(NIPAm‐co ‐AAc) hydrogels charged with S‐nitrosoglutathione (GSNO), released nitric oxide (NO) spontaneously during hydration. The decrease in the pore diameter led to a twofold to threefold increase in the rate of water absorption and a fourfold to sixfold increase in the rate of NO release of the hydrogels. F127 can be used to change the pore morphology of P(NIPAm‐co ‐AAc) hydrogels, with concomitant changes in their rate of hydration and NO release from GSNO, opening a new perspective for their use in topical NO delivery.

更新日期：2020-02-04

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