犬嗜铬细胞瘤相关的异位库欣综合征：一例病例报告。,BMC Veterinary Research

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犬嗜铬细胞瘤相关的异位库欣综合征：一例病例报告。
BMC Veterinary Research ( IF 2.3 ) Pub Date : 2020-02-03 , DOI: 10.1186/s12917-020-2244-7
Sungin Lee ₁ , Aeri Lee ₁ , Suh-Hyun Chai ₁ , Seulji Lee ₁ , Oh-Kyeong Kweon ₁ , Wan Hee Kim ₁

Affiliation

背景技术在人类医学中，已经报道了与恶性肿瘤例如小细胞肺癌，支气管类癌和嗜铬细胞瘤相关的异位库欣综合征（ECS）。然而，与嗜铬细胞瘤有关的ECS尚未在犬中报道。病例介绍一名11岁的去势男性苏格兰梗犬被诊断出左肾上腺肿块。根据临床体征，怀疑库欣氏综合症，包括盆肚，多尿，多尿，双侧脱发，反复脓皮病和角质层结皮。库欣综合征是根据一致的临床体征和反复的促肾上腺皮质激素（ACTH）刺激试验诊断出来的。此外，对血浆血浆间肾上腺素/去甲肾上腺素的分离试验提示嗜铬细胞瘤。药物治疗后，用三氯stane和苯氧基苯甲胺进行单侧肾上腺切除术。组织病理学证实诊断为嗜铬细胞瘤而无皮质病变。手术后，未进行任何药物治疗的情况下，偏甲肾上腺素/去甲肾上腺素的分馏以及低剂量地塞米松抑制作用和ACTH刺激试验的结果均在正常范围内。直至手术后8个月，胸，腹部X线和超声检查均无临床症状或复发和转移的迹象。结论嗜铬细胞瘤应被视为对患有肾上腺肿瘤的库欣综合征的狗的鉴别诊断。迅速诊断和手术干预可以预后良好。组织病理学证实诊断为嗜铬细胞瘤而无皮质病变。手术后，未进行任何药物治疗的情况下，偏甲肾上腺素/去甲肾上腺素的分馏以及低剂量地塞米松抑制作用和ACTH刺激试验的结果均在正常范围内。直至手术后8个月，胸，腹部X线和超声检查均无临床症状或复发和转移的迹象。结论嗜铬细胞瘤应被视为对患有肾上腺肿瘤的库欣综合征的狗的鉴别诊断。迅速诊断和手术干预可以预后良好。组织病理学证实诊断为嗜铬细胞瘤而无皮质病变。手术后，未进行任何药物治疗的情况下，偏甲肾上腺素/去甲肾上腺素的分馏以及低剂量地塞米松抑制作用和ACTH刺激试验的结果均在正常范围内。直至手术后8个月，胸，腹部X线和超声检查均无临床症状或复发和转移的迹象。结论嗜铬细胞瘤应被视为对患有肾上腺肿瘤的库欣综合征的狗的鉴别诊断。迅速诊断和手术干预可以预后良好。直至手术后8个月，胸，腹部X线和超声检查均无临床症状或复发和转移的迹象。结论嗜铬细胞瘤应被视为对患有肾上腺肿瘤的库欣综合征的狗的鉴别诊断。迅速诊断和手术干预可以预后良好。直至手术后8个月，胸，腹部X线和超声检查均无临床症状或复发和转移的迹象。结论嗜铬细胞瘤应被视为对患有肾上腺肿瘤的库欣综合征的狗的鉴别诊断。迅速诊断和手术干预可以预后良好。

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Ectopic Cushing's syndrome associated with a pheochromocytoma in a dog: a case report.

BACKGROUND Ectopic Cushing's syndrome (ECS) associated with malignant tumors, such as small cell lung carcinoma, bronchial carcinoids, and pheochromocytoma, has been reported in human medicine. However, ECS related to pheochromocytoma has not been reported in dogs. CASE PRESENTATION An 11-year-old castrated, male Scottish terrier was diagnosed with a left adrenal mass. Cushing's syndrome was suspected based on clinical signs, including pot belly, polyuria, polydipsia, bilateral alopecia, recurrent pyoderma, and calcinosis cutis. Cushing's syndrome was diagnosed on the basis of consistent clinical signs and repeated adrenocorticotropic hormone (ACTH) stimulation tests. In addition, tests for fractionated plasma metanephrine/normetanephrine suggested a pheochromocytoma. Unilateral adrenalectomy was performed after medical management with trilostane and phenoxybenzamine. Histopathology confirmed a diagnosis of pheochromocytoma without cortical lesions. After surgery, fractionated metanephrine/normetanephrine and the findings of low-dose dexamethasone suppression and ACTH stimulation tests were within the normal ranges without any medication. There were no clinical signs or evidence of recurrence and metastasis on thoracic and abdominal X-rays and ultrasonography up to 8 months after surgery. CONCLUSIONS Pheochromocytoma should be considered a differential diagnosis for dogs with Cushing's syndrome with an adrenal tumor. A good prognosis can be expected with prompt diagnosis and surgical intervention.

更新日期：2020-02-04

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