Design of Red Emissive Carbon Dots: Robust Performance for Analytical Applications in Pesticide Monitoring.,Analytical Chemistry

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Design of Red Emissive Carbon Dots: Robust Performance for Analytical Applications in Pesticide Monitoring.
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-02-07 , DOI: 10.1021/acs.analchem.9b04917
Hongxia Li _{1,

2} , Dandan Su ₁ , Hao Gao ₃ , Xu Yan ₁ , Deshuai Kong ₁ , Rui Jin ₁ , Xiaomin Liu ₁ , Chenguang Wang ₁ , Geyu Lu ₁

Affiliation

Synthesis of red emissive carbon dots (CDs) is highly desirable for sensing applications, as they still remain as bottlenecks in terms of precursor synthesis and product purification. Herein, we have designed a new strategy for realizing efficient red emissive CD optimal emission at 610 nm (fluorescence quantum yield ca. 24.0%) based on solvothermal treatment of citric acid and thiourea using dimethylformamide as solvent. Further investigations reveal that the conjugating sp2-domain controlling the incorporation of nitrogen and surface engineering are mainly responsible for the obtained red emission of CDs. Taking advantage of optical properties and abundant surface functional groups, CDs were considered to facilely construct a ratiometric fluorescent platform for quantifying trace levels of organophosphorus pesticides (OPs). Combining the acetylcholinesterase-mediated polymerization of dopamine and the inhibition of pesticide toward the enzyme, the degree of polymerization of dopamine rationally depends on the concentration of OPs. By measuring the fluorescence intensity ratio, the proposed platform exhibited highly selective and robust performance toward OPs, displaying ultrasensitive recognition in the pg L-1 level. The multiexcitation format could efficiently shield background interference from complex samples by introducing a self-calibrated reference signal, which affords accurate and reliable quantitative information, endowing CDs as a universal candidate for a biosensing application by combining target-specific recognition elements.

中文翻译：

红色发射碳点的设计：农药监测中分析应用的稳健性能。

红色发光碳点（CD）的合成对于传感应用非常必要，因为在前体合成和产物纯化方面，它们仍然是瓶颈。在此，我们设计了一种新的策略，该方法以二甲基甲酰胺为溶剂对柠檬酸和硫脲进行溶剂热处理，从而在610 nm处实现高效的红色发射CD最佳发射（荧光量子产率约为24.0％）。进一步的研究表明，控制氮的掺入和表面工程的共轭sp2-结构域主要负责获得的CD红色发射。利用光学特性和丰富的表面官能团，CD被认为可以方便地构建用于定量痕量有机磷农药（OPs）的比例荧光平台。结合乙酰胆碱酯酶介导的多巴胺聚合和农药对酶的抑制作用，多巴胺的聚合程度合理地取决于OP的浓度。通过测量荧光强度比，所提出的平台对OP表现出高度的选择性和强大的性能，在pg L-1水平上显示出超灵敏的识别能力。多重激发格式可以通过引入自校准参考信号来有效地屏蔽复杂样品的背景干扰，该参考信号提供了准确而可靠的定量信息，通过结合目标特异性识别元素，使CD成为生物传感应用的通用候选者。多巴胺的聚合程度合理地取决于OP的浓度。通过测量荧光强度比，所提出的平台对OP表现出高度的选择性和强大的性能，在pg L-1水平上显示出超灵敏的识别能力。多重激发格式可以通过引入自校准参考信号来有效地屏蔽复杂样品的背景干扰，该参考信号提供了准确而可靠的定量信息，通过结合目标特异性识别元素，使CD成为生物传感应用的通用候选者。多巴胺的聚合程度合理地取决于OP的浓度。通过测量荧光强度比，所提出的平台对OP表现出高度的选择性和强大的性能，在pg L-1水平上显示出超灵敏的识别能力。多重激发格式可以通过引入自校准参考信号来有效地屏蔽复杂样品的背景干扰，该参考信号提供了准确而可靠的定量信息，通过结合目标特异性识别元素，使CD成为生物传感应用的通用候选者。

更新日期：2020-02-07

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