Alkyl Tosylates as Alkylating Reagents in the Catellani Reaction,Synthesis

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Alkyl Tosylates as Alkylating Reagents in the Catellani Reaction
Synthesis ( IF 2.2 ) Pub Date : 2020-01-30 , DOI: 10.1055/s-0039-1690801
Qianwen Gao ₁ , Ze-Shui Liu ₁ , Yu Hua ₁ , Siwei Zhou ₁ , Hong-Gang Cheng ₁ , Qianghui Zhou _{1,

2}

Affiliation

A cooperative catalytic system involving a Pd/XPhos complex and inexpensive 5-norbornene-2-carbonitrile that enables the use of alkyl tosylates as alkylating reagents in the Catellani reaction has been developed. This mild, scalable protocol is compatible with a range of readily available functionalized aryl iodides and alkyl tosylates, as well as terminating olefins (45 examples, up to 97% yield).

中文翻译：

烷基甲苯磺酸盐作为卡泰拉尼反应中的烷基化试剂

已开发出一种涉及Pd / XPhos络合物和廉价的5-降冰片烯-2-腈的协同催化系统，该催化系统能够在Catellani反应中使用烷基甲苯磺酸盐作为烷基化试剂。这种温和的，可扩展的方案与一系列容易获得的官能化的芳基碘化物和烷基甲苯磺酸盐以及端基烯烃兼容（45个实例，产率高达97％）。

更新日期：2020-01-31

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