Assembly-Controlled Magnetic Nanoparticle Clusters as MRI Contrast Agents,ACS Biomaterials Science & Engineering

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Assembly-Controlled Magnetic Nanoparticle Clusters as MRI Contrast Agents
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-01-29 , DOI: 10.1021/acsbiomaterials.9b01198
Zhongyuan Cai ₁ , Changqiang Wu _{1,

2} , Li Yang ₁ , Dan Wang ₃ , Hua Ai _{1,

3}

Affiliation

Magnetic nanoparticle clusters have been the subject of extensive studies examining their use as magnetic resonance imaging (MRI) probes in recent years because of their excellent contrast enhancement capability. Identification of the key factors affecting transverse (T₂) relaxivity in vitro and visualization in vivo is critical for the rational design of magnetic nanoclusters. In this review, we discuss the relationship between the structural characteristics of the magnetic nanoclusters (cluster size, interparticle spacing, and shell thickness) and the T₂ relaxivity and suggest key approaches for optimizing the structures of the nanoclusters. Examples of applications in tissue imaging and cell tracking are discussed.

中文翻译：

组装控制的磁性纳米粒子簇作为MRI造影剂

近年来，磁性纳米粒子簇因其出色的对比度增强能力而成为研究磁共振成像（MRI）探针的广泛研究对象。鉴定影响横向（T ₂）弛豫的关键因素在体外和体内可视化对于合理设计磁性纳米簇至关重要。在这篇综述中，我们讨论了磁性纳米团簇的结构特征（团簇尺寸，粒子间间距和壳厚度）与T ₂弛豫性之间的关系，并提出了优化纳米团簇结构的关键方法。讨论了在组织成像和细胞跟踪中的应用实例。

更新日期：2020-01-29

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