Bacterial biopolymers: from pathogenesis to advanced materials.,Nature Reviews Microbiology

当前位置： X-MOL 学术 › Nat. Rev. Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bacterial biopolymers: from pathogenesis to advanced materials.
Nature Reviews Microbiology ( IF 69.2 ) Pub Date : 2020-01-28 , DOI: 10.1038/s41579-019-0313-3
M Fata Moradali ₁ , Bernd H A Rehm ₂

Affiliation

Bacteria are prime cell factories that can efficiently convert carbon and nitrogen sources into a large diversity of intracellular and extracellular biopolymers, such as polysaccharides, polyamides, polyesters, polyphosphates, extracellular DNA and proteinaceous components. Bacterial polymers have important roles in pathogenicity, and their varied chemical and material properties make them suitable for medical and industrial applications. The same biopolymers when produced by pathogenic bacteria function as major virulence factors, whereas when they are produced by non-pathogenic bacteria, they become food ingredients or biomaterials. Interdisciplinary research has shed light on the molecular mechanisms of bacterial polymer synthesis, identified new targets for antibacterial drugs and informed synthetic biology approaches to design and manufacture innovative materials. This Review summarizes the role of bacterial polymers in pathogenesis, their synthesis and their material properties as well as approaches to design cell factories for production of tailor-made bio-based materials suitable for high-value applications.

中文翻译：

细菌生物聚合物：从发病机制到先进材料。

细菌是主要的细胞工厂，可以有效地将碳源和氮源转化为多种细胞内和细胞外生物聚合物，例如多糖、聚酰胺、聚酯、多磷酸盐、细胞外DNA和蛋白质成分。细菌聚合物在致病性中发挥重要作用，其不同的化学和材料特性使其适合医疗和工业应用。当由病原细菌产生时，相同的生物聚合物充当主要毒力因子，而当它们由非病原细菌产生时，它们则成为食品成分或生物材料。跨学科研究揭示了细菌聚合物合成的分子机制，确定了抗菌药物的新靶点，并为设计和制造创新材料的合成生物学方法提供了信息。本综述总结了细菌聚合物在发病机制、其合成和材料特性中的作用，以及设计细胞工厂以生产适合高价值应用的定制生物基材料的方法。

更新日期：2020-01-28

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南