Refractive index, FTIR and Uv–vis absorption study of acefylline piperazine, chlorpheniramine maleate, thiamine hydrochloride was done to investigate the solute-solvent interactions. The interaction of drugs (AP, CPM, TAD) studied in aqueous, aqueous methanol and aqueous ethylene glycol systems at 303 K. Specific refraction, Molar refraction and polarizability of drugs in aqueous and aqueous alcoholic systems was calculated by using Lorentz-Lorentz equation. FTIR study of drugs in aqueous and aqueous alcoholic systems was undertaken to analyze the compatibility of drugs in studied systems. The UV–vis absorption study has also been done to interpret the interaction patterns occurring in drugs and solvent systems.

进行了醋菲林哌嗪，马来酸氯苯那敏，盐酸硫胺素的折射率，FTIR和Uv-vis吸收研究，以研究溶质与溶剂的相互作用。在303 K的水性，水性甲醇和乙二醇水溶液体系中研究了药物（AP，CPM，TAD）的相互作用。使用Lorentz-Lorentz方程计算了水性和水性醇体系中药物的比折射，摩尔折射和极化率。进行了水性和水性酒精系统中药物的FTIR研究，以分析所研究系统中药物的相容性。还进行了紫外线可见吸收研究，以解释药物和溶剂系统中发生的相互作用模式。