Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.,ACS Medicinal Chemistry Letters

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Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-01-24 , DOI: 10.1021/acsmedchemlett.9b00623
Pedro A Sánchez-Murcia ₁ , Sonia de Castro ₁ , Carlos García-Aparicio ₁ , M Angeles Jiménez ₂ , Angela Corona ₃ , Enzo Tramontano ₃ , Nicolas Sluis-Cremer ₄ , Luis Menéndez-Arias ₅ , Sonsoles Velázquez ₁ , Federico Gago ₆ , María-José Camarasa ₁

Affiliation

A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.

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