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Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy.
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-01-28 , DOI: 10.1016/j.jconrel.2020.01.048 Qingqing Guan 1 , Ruomi Guo 2 , Shihui Huang 3 , Fan Zhang 1 , Jie Liu 1 , Zhiyong Wang 3 , Xi Yang 1 , Xintao Shuai 3 , Zhong Cao 1
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-01-28 , DOI: 10.1016/j.jconrel.2020.01.048 Qingqing Guan 1 , Ruomi Guo 2 , Shihui Huang 3 , Fan Zhang 1 , Jie Liu 1 , Zhiyong Wang 3 , Xi Yang 1 , Xintao Shuai 3 , Zhong Cao 1
Affiliation
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Iron-based nanomaterials as the main ferroptosis-inducing platforms are more promising because iron itself is a key component in the Fenton reaction to produce ROS. However, the Fe dose needs to be very high in order to induce ferroptosis-based cancer treatment using the SPIO NPs. Therefore, it is still of great challenge to enhance the efficacy of ferroptosis-based cancer therapy by associating the iron-based nanomaterials with other components and therapeutic modalities. In this study, sorafenib (SRF) and ultrasmall SPIO nanoparticles were loaded into the mesopores and onto the surface of MPDA NPs to form SRF@MPDA-SPIO nanoparticles. SPIO loading endowed the system with iron-supply for ferroptosis and made the system MRI-visible. Meanwhile, SRF was able to induce ferroptosis in cancer cells with lower Fe dose. Furthermore, the heat generated by MPDA NPs upon laser irradiation offered a moderate PTT to boost the ferroptosis effect. The SRF@MPDA-SPIO exhibited biocompatibility highly desirable for in vivo application and superior anticancer therapy via the combination of ferroptosis and photothermal therapy.
中文翻译：
带有索拉非尼和SPIO纳米粒子的中孔聚多巴胺，用于MRI指导的肥大性前列腺癌的治疗。
铁基纳米材料作为主要的促肥大作用的诱导平台更具前景，因为铁本身是芬顿反应产生ROS的关键成分。然而，为了使用SPIO NPs诱导基于肥大病的癌症治疗，Fe剂量必须很高。因此，通过使铁基纳米材料与其他组分和治疗方式相关联来提高基于铁质病的癌症治疗的效率仍然是巨大的挑战。在这项研究中，索拉非尼（SRF）和超小型SPIO纳米颗粒被加载到中孔和MPDA NP的表面上，形成SRF @ MPDA-SPIO纳米颗粒。SPIO加载为系统提供了铁供肥育作用，并使该系统在MRI中可见。同时，SRF能够以较低的Fe剂量诱导癌细胞的肥大化。此外，MPDA NP在激光照射下产生的热量提供了适度的PTT，以增强肥大作用。SRF @ MPDA-SPIO表现出非常适合于体内应用的生物相容性，并且通过结合肥大病和光热疗法实现了出色的抗癌治疗。
更新日期：2020-01-29
中文翻译：
带有索拉非尼和SPIO纳米粒子的中孔聚多巴胺，用于MRI指导的肥大性前列腺癌的治疗。
铁基纳米材料作为主要的促肥大作用的诱导平台更具前景，因为铁本身是芬顿反应产生ROS的关键成分。然而，为了使用SPIO NPs诱导基于肥大病的癌症治疗，Fe剂量必须很高。因此，通过使铁基纳米材料与其他组分和治疗方式相关联来提高基于铁质病的癌症治疗的效率仍然是巨大的挑战。在这项研究中，索拉非尼（SRF）和超小型SPIO纳米颗粒被加载到中孔和MPDA NP的表面上，形成SRF @ MPDA-SPIO纳米颗粒。SPIO加载为系统提供了铁供肥育作用，并使该系统在MRI中可见。同时，SRF能够以较低的Fe剂量诱导癌细胞的肥大化。此外，MPDA NP在激光照射下产生的热量提供了适度的PTT，以增强肥大作用。SRF @ MPDA-SPIO表现出非常适合于体内应用的生物相容性，并且通过结合肥大病和光热疗法实现了出色的抗癌治疗。
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