Koch Institute for Integrative Cancer ResearchMassachusetts Institute of Technology Cambridge MA 02139 USA
Department of BioengineeringKoch Institute for Integrative Cancer ResearchMassachusetts Institute of Technology Cambridge MA 02139 USA
Current address: Materials Science and EngineeringStanford University 496 Lomita Mall Stanford CA 94305 USA
Institute for Medical Engineering and ScienceMassachusetts Institute of Technology Cambridge MA 02139 USA
Department of ChemistryKoch Institute for Integrative Cancer ResearchMassachusetts Institute of Technology Cambridge MA 02139 USA
Department of Pediatric OncologyDana-Farber/Boston Children's Cancer and Blood Disorders Center Boston MA 02115 USA
Department of MedicineBrigham and Women's Hospital and Harvard Medical School Boston MA 02115 USA
Broad Institute of Massachusetts Institute of Technology and Harvard Cambridge MA 02139 USA
Howard Hughes Medical Institute Cambridge MA 02139 USA
Department of Chemical EngineeringMassachusetts Institute of Technology Cambridge MA 02139 USA
Layer‐by‐layer nanoparticles functionalized with protease‐responsive peptide biomarkers and loaded with siRNA mediate noninvasive urinary‐based diagnostics in mouse models of three different cancers with simultaneous gene silencing in flank and metastatic mouse models of ovarian cancer. This work provides a modular nanotheranostic platform to both perturb and characterize tumors, allowing for simultaneous treatment and monitoring of disease, as reported by P. T. Hammond et al. in their Research Article (DOI: 10.1002/anie.201911762).
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