Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.,Organic Letters

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Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.
Organic Letters ( IF 4.9 ) Pub Date : 2020-01-29 , DOI: 10.1021/acs.orglett.9b04490
Zong-Jie Wang ₁ , Haibo Zhou ₁ , Guannan Zhong ₁ , Liujie Huo ₁ , Ya-Jie Tang ₁ , Youming Zhang ₁ , Xiaoying Bian ₁

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Genome mining of Fulvivirga sp. W222 revealed a desferrioxamine-like biosynthetic gene cluster containing an unknown gene fulF that is conserved in many Bacteroidetes species. A series of primary amine-acylated desferrioxamine G1 analogues, fulvivirgamides, were identified, and fulvivirgamides A2, B2, B3, and B4 (1-4) were purified and characterized. The function of FulF, which is a novel acyltransferase for the acylation of the primary amine of Desferrioxamine G1, was verified by heterologous expression and feeding experiments.

中文翻译：

海洋滑翔细菌中伯胺酰化去铁胺的基因组挖掘和生物合成。

Fulvivirga sp。的基因组挖掘 W222揭示了一种类似去铁草胺的生物合成基因簇，其中包含未知的fulF基因，该基因在许多拟杆菌属物种中均保守。鉴定了一系列伯胺酰化的去铁草胺G1类似物，富氟吡虫酰胺，并纯化和表征了富氟吡虫胺A2，B2，B3和B4（1-4）。FulF的功能是一种新型的酰基转移酶，用于去铁氧胺G1的伯胺的酰化反应，已通过异源表达和补料实验进行了验证。

更新日期：2020-01-29

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