BiO2-x Nanosheets as Radiosensitizers with Catalase-Like Activity for Hypoxia Alleviation and Enhancement of the Radiotherapy of Tumors.,Inorganic Chemistry

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BiO2-x Nanosheets as Radiosensitizers with Catalase-Like Activity for Hypoxia Alleviation and Enhancement of the Radiotherapy of Tumors.
Inorganic Chemistry ( IF 4.3 ) Pub Date : 2020-01-28 , DOI: 10.1021/acs.inorgchem.9b03280
Huimin Liu _{1,

2} , Ran Cheng _{1,

2} , Xinghua Dong _{2,

3} , Shuang Zhu ₂ , Ruyi Zhou _{2,

3} , Liang Yan ₂ , Chenyang Zhang _{2,

3} , Qing Wang ₁ , Zhanjun Gu _{2,

3} , Yuliang Zhao _{3,

4}

Affiliation

Tumor hypoxia is known to be one of the vital factors that aggravate tumor resistance to radiation therapy (RT) in which oxygen plays a critical role in tumor destruction. Herein, we synthesize a simple nanoradiosensitizer based on ultrathin BiO2-x nanosheets (NSs) modified with Tween 20 (T-BiO2-x NSs) to overcome the hypoxia-induced radioresistance as well as increase the efficacy of RT. On the one hand, bismuth as a high-Z element can effectively enhance the sensitivity of RT by depositing a higher radiation dose in tumors. The semiconductor property also endows its photocatalytic ability to produce extra reactive oxygen species (ROS) by reaction with the surrounding water. On the other hand, the defect-abundant BiO2-x NSs are also found to decompose the highly expressed hydrogen peroxide (H2O2) at the tumor site into oxygen (O2) for combating hypoxia. Both in vitro and in vivo experiments indicate that the as-prepared T-BiO2-x NSs could effectively inhibit tumor growth with X-ray irradiation. Our work thus provides a simple nanoradiosensitizer with multifunctionalities for increasing the RT efficacy while alleviating tumor hypoxia at the same time.

中文翻译：

具有过氧化氢酶活性的BiO2-x纳米片作为放射增敏剂，可减轻和增强肿瘤的放射治疗。

已知肿瘤缺氧是加重肿瘤对放射治疗（RT）的抵抗力的重要因素之一，其中氧气在破坏肿瘤中起关键作用。在本文中，我们合成了一种简单的纳米放射增敏剂，其基于用Tween 20修饰的超薄BiO2-x纳米片（NSs）（T-BiO2-x NSs）来克服缺氧诱导的放射抵抗力并提高RT的疗效。一方面，铋作为高Z元素可以通过在肿瘤中沉积更高的放射剂量来有效增强RT的敏感性。半导体特性还赋予了其光催化能力，可通过与周围的水反应产生额外的活性氧（ROS）。另一方面，还发现缺陷多的BiO2-x NSs将肿瘤部位的高表达过氧化氢（H2O2）分解为氧气（O2），以对抗缺氧。体外和体内实验均表明，制备的T-BiO2-x NSs可以有效地抑制X射线照射下的肿瘤生长。因此，我们的工作提供了一种简单的具有多种功能的纳米放射增敏剂，可提高RT疗效，同时缓解肿瘤缺氧。

更新日期：2020-01-29

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