B cells, plasma cells and antibody repertoires in the tumour microenvironment.,Nature Reviews Immunology

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B cells, plasma cells and antibody repertoires in the tumour microenvironment.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-01-27 , DOI: 10.1038/s41577-019-0257-x
George V Sharonov _{1,

2,

3} , Ekaterina O Serebrovskaya _{2,

3} , Diana V Yuzhakova ₁ , Olga V Britanova _{1,

2,

3} , Dmitriy M Chudakov _{1,

2,

3,

4}

Affiliation

Recent data show that B cells and plasma cells located in tumours or in tumour-draining lymph nodes can have important roles in shaping antitumour immune responses. In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the B cell phenotype. Furthermore, the isotype and specificity of the antibodies produced by plasma cells can drive distinct immune responses. Here we summarize our current knowledge of the roles of B cells and antibodies in the tumour microenvironment. Moreover, we discuss the potential of using immunoglobulin repertoires as a source of tumour-specific receptors for immunotherapy or as biomarkers to predict the efficacy of immunotherapeutic interventions.

中文翻译：

肿瘤微环境中的B细胞，浆细胞和抗体库。

最近的数据表明，位于肿瘤或引流肿瘤的淋巴结中的B细胞和浆细胞在形成抗肿瘤免疫应答中起重要作用。在与肿瘤相关的三级淋巴样结构中，T细胞和B细胞相互作用并进行协同选择，特化和克隆扩增。重要的是，B细胞可以向T细胞呈递同源的肿瘤衍生抗原，而这种相互作用的功能后果则由B细胞表型决定。此外，浆细胞产生的抗体的同种型和特异性可以驱动不同的免疫反应。在这里，我们总结了我们目前对B细胞和抗体在肿瘤微环境中的作用的认识。此外，

更新日期：2020-01-27

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