This study aims to investigate the neuroprotective effects of 6‴-feruloylspinosin (6-FS), one of the main active flavonoid components in Sour Jujube seeds, on beta-amyloid (Aβ) protein transgenic Caenorhabditis elegans (GMC101) and PC12 cells, and determine the molecular mechanism of its action. We found that 6-FS could ameliorate the progression of the Alzheimer's disease (AD) phenotype by delaying the aging, decreasing the rate of paralysis, enhancing resistance to heat stress, and increasing the chemotaxis ability, and promotes autophagy activity though autophagy/lysosome pathway in GMC101. Furthermore, 6-FS reduced Aβ-induced toxicity by inhibiting the deposition of Aβ and the aggregated proteins, increasing the level of mitophagy in PC12 through promoting the expression of Pink1/Parkin in the mitophagy pathway. Our findings suggest that 6-FS may be used as a medicinal supplement for treating AD.

中文翻译：

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6 -Feruloylspinosin通过促进秀丽隐杆线虫（GMC101）和PC12细胞中的线粒体吞噬减轻β-淀粉样蛋白诱导的毒性。

这项研究旨在研究酸枣种子中主要的活性类黄酮成分之一6β-阿魏酰基纺丝蛋白（6-FS）对转基因秀丽隐杆线虫（GMC101）和PC12细胞的β-淀粉样蛋白（Aβ）的神经保护作用，以及确定其作用的分子机理。我们发现6-FS可以通过延缓衰老，降低麻痹率，增强对热应激的抵抗力和增加趋化能力来改善阿尔茨海默氏病（AD）表型的进展，并通过自噬/溶酶体途径促进自噬活性。在GMC101中。此外，6-FS通过抑制Aβ和聚集蛋白的沉积来降低Aβ诱导的毒性，并通过促进Pink1 / Parkin在细胞吞噬途径中的表达来提高PC12中的细胞吞噬水平。