Biocascade Synthesis of L‐Tyrosine Derivatives by Coupling a Thermophilic Tyrosine Phenol‐Lyase and L‐Lactate Oxidase,European Journal of Organic Chemistry

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Biocascade Synthesis of L‐Tyrosine Derivatives by Coupling a Thermophilic Tyrosine Phenol‐Lyase and L‐Lactate Oxidase
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-02-18 , DOI: 10.1002/ejoc.202000061
Guosi Li ₁ , Jiazhang Lian ₁ , Hailong Xue ₁ , Yiqi Jiang ₁ , Shuyun Ju ₁ , Mianbin Wu ₁ , Jianping Lin ₁ , Lirong Yang ₁

Affiliation

A one‐pot biocascade of two enzymatic steps catalyzed by a l‐lactate oxidase (AvLOX) and a designed thermophilic tyrosine‐phenol lyase (TTPL) mutant was used for the synthesis of l‐tyrosine derivatives, in which pyruvate was in situ generated by AvLOX from readily available bio‐based l‐lactate.