A framework for advancing our understanding of cancer-associated fibroblasts.,Nature Reviews Cancer

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A framework for advancing our understanding of cancer-associated fibroblasts.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2020-01-24 , DOI: 10.1038/s41568-019-0238-1
Erik Sahai ₁ , Igor Astsaturov ₂ , Edna Cukierman ₃ , David G DeNardo ₄ , Mikala Egeblad ₅ , Ronald M Evans _{6,

7} , Douglas Fearon _{5,

8} , Florian R Greten _{9,

10} , Sunil R Hingorani ₁₁ , Tony Hunter ₁₂ , Richard O Hynes ₁₃ , Rakesh K Jain ₁₄ , Tobias Janowitz _{5,

15} , Claus Jorgensen ₁₆ , Alec C Kimmelman ₁₇ , Mikhail G Kolonin ₁₈ , Robert G Maki _{5,

19,

20} , R Scott Powers ₂₁ , Ellen Puré ₂₂ , Daniel C Ramirez ₂₃ , Ruth Scherz-Shouval ₂₄ , Mara H Sherman ₂₅ , Sheila Stewart ₂₆ , Thea D Tlsty _{27,

28} , David A Tuveson ₅ , Fiona M Watt ₂₉ , Valerie Weaver ₃₀ , Ashani T Weeraratna ₃₁ , Zena Werb ₃₂

Affiliation

The Francis Crick Institute, London, UK.
Marvin and Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
Cancer Biology Program, Marvin & Concetta Greenberg Pancreatic Cancer Institute, Fox Chase Cancer Center, Philadelphia, PA, USA.
Division of Oncology, Washington University Medical School, St Louis, MO, USA.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA.
Weill Cornell Medicine, New York, NY, USA.
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt, Germany.
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Edwin L Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Northwell Health Cancer Institute, New Hyde Park, NY, USA.
Cancer Research UK Manchester Institute, University of Manchester, Nether Alderley, UK.
Department of Radiation Oncology, Perlmutter Cancer Center, New York University Medical Center, New York, NY, USA.
Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA.
Northwell Health Cancer Institute, New York, NY, USA.
Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Department of Pathology, Stony Brook University, Stony Brook, NY, USA.
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zucker School of Medicine at Hofstra/Northwell Health System, New York, NY, USA.
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
Department of Cell Biology and Physiology, Department of Medicine, ICCE Institute, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA, USA.
Department of Pathology, UCSF, San Francisco, CA, USA.
Centre for Stem Cells and Regenerative Medicine, King's College London, Guy's Hospital, London, UK.
Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

中文翻译：

增进我们对癌症相关成纤维细胞的理解的框架。

癌症相关成纤维细胞（CAF）是肿瘤微环境的关键组成部分，具有多种功能，包括基质沉积和重塑、与癌细胞广泛的相互信号相互作用以及与浸润白细胞的串扰。因此，它们是优化癌症治疗策略的潜在目标。然而，在持续尝试调节 CAF 以获得治疗益处时，存在许多挑战。这些包括我们对 CAF 起源的理解的局限性和 CAF 功能的异质性，需要保留一些抗肿瘤功能。在 CAF 生物学领域专家会议的基础上，我们在这份共识声明中总结了我们目前的知识，并提出了一个框架，以加深我们对肿瘤微环境中这种关键细胞类型的理解。

更新日期：2020-01-24

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