红细胞分布宽度（RDW）在结直肠癌中的预后价值。来自591名患者的单中心队列研究结果。,Scientific Reports

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红细胞分布宽度（RDW）在结直肠癌中的预后价值。来自591名患者的单中心队列研究结果。
Scientific Reports ( IF 3.8 ) Pub Date : 2020-01-23 , DOI: 10.1038/s41598-020-57721-4
Corrado Pedrazzani ₁ , Marzia Tripepi ₁ , Giulia Turri ₁ , Eduardo Fernandes ₂ , Giovanni Scotton ₁ , Simone Conci ₁ , Tommaso Campagnaro ₁ , Andrea Ruzzenente ₁ , Alfredo Guglielmi ₁

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越来越多的证据提倡RDW在各种肿瘤中的预后作用。我们分析了591例患者，以评估RDW是否是大肠癌（CRC）患者总体（OS）和癌症相关生存（CRS）的预后因素。从回顾性数据库中检索数据。RDW的最佳截止值设置为14.1％；因此，考虑了两组：值等于或低于14.1％（L-RDW）的组和值高于14.1％（H-RDW）的组。RDW的平均值从pT1上升到pT4肿瘤。H-RDW与高于平均年龄，病变的结肠位置，pT和TNM分期相关。最后，H-RDW与手术意图显着相关：接受非根治性切除术的患者中有近50％出现了H-RDW，而R0切除术中这一比例为19.3％。H-RDW患者的OS显着降低。两组的CRS相似。根据TNM分期对患者进行分层，仅在早期阶段将较差的OS与H-RDW相关联，而II-IV期没有差异。多因素分析证实，H-RDW不是独立的预后因素。尽管H-RDW与某些负面的临床病理因素相关，但它似乎并没有独立影响OS和CRS。

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Prognostic value of red cell distribution width (RDW) in colorectal cancer. Results from a single-center cohort on 591 patients.

Increasing evidence advocates the prognostic role of RDW in various tumours. We analysed 591 patients to assess whether RDW is a prognostic factor for overall (OS) and cancer-related survival (CRS) for patients with colorectal cancer (CRC). The data were retrieved from a retrospective database. The optimal cut-off value for RDW was set at 14.1%; accordingly, two groups were considered: those with a value equal or lower than 14.1% (L-RDW), and those with a value higher than 14.1% (H-RDW). The mean value of RDW rose from pT1 to pT4 tumours. H-RDW correlated with age above the mean, colonic location of the lesion, pT and TNM stage. Finally, H-RDW was significantly associated with the intent of surgery: almost 50% of patients who underwent a non-curative resection presented H-RDW, compared to 19.3% in R0 resections. OS was significantly lower in patients with H-RDW. CRS was similar in the two groups. Stratifying patients according to TNM stage worse OS was associated with H-RDW only in early stages, whereas there was no difference for stages II-IV. Multivariate analysis confirmed that H-RDW was not an independent prognostic factor. Although H-RDW correlated with some negative clinical-pathological factors, it did not seem to independently influence OS and CRS.

更新日期：2020-01-23

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