Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan Nelliella nelliiformis.,Journal of Natural Products

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Kinase-Inhibitory Nucleoside Derivatives from the Pacific Bryozoan Nelliella nelliiformis.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-01-21 , DOI: 10.1021/acs.jnatprod.9b01231
Joe Bracegirdle _{1,

2} , Dennis P Gordon ₃ , Joanne E Harvey _{1,

2} , Robert A Keyzers _{1,

2}

Affiliation

Marine organisms are a valuable source of bioactive natural products, yet bryozoan invertebrates have been relatively understudied. Herein, we report nelliellosides A and B, new secondary metabolites of the Pacific bryozoan Nelliella nelliiformis, found using NMR-guided isolation. Their structures, including absolute configurations, were elucidated using spectroscopic and chromatographic techniques. Total synthesis of the natural products and four analogues was also achieved, in addition to an assessment of their biological activity, especially kinase inhibition.

中文翻译：

来自太平洋Bryozoan Nelliella nelliiformis的激酶抑制性核苷衍生物。

海洋生物是生物活性天然产物的宝贵来源，但对苔藓无脊椎动物的研究相对较少。在本文中，我们报告了核果糖苷A和B，这是使用NMR指导分离发现的太平洋苔藓苔藓菌Nelliella nelliiformis的新的次级代谢产物。使用光谱和色谱技术阐明了它们的结构，包括绝对构型。除了评估其生物活性，特别是激酶抑制作用，还实现了天然产物和四种类似物的全合成。

更新日期：2020-01-22

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