Biomedical Applications of Calixarenes: State of the Art and Perspectives,Angewandte Chemie International Edition

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Biomedical Applications of Calixarenes: State of the Art and Perspectives
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-01-21 , DOI: 10.1002/anie.201916380
Yu-Chen Pan ₁ , Xin-Yue Hu ₁ , Dong-Sheng Guo ₁

Affiliation

Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application possibilities due to their ease of modification, which allows one to establish a large molecular library as a material basis for diverse biomedical applications. Moreover, CAs and their derivatives engage in various noncovalent interactions for the facile recognition of guests including bioactive molecules and are also important building blocks for the fabrication of supramolecular architectures. In view of their molecular recognition and self‐assembly properties, CAs are extensively applied in biosensing, bioimaging, and drug/gene delivery. Additionally, some CA derivatives exhibit biological activities and can therefore be used as new therapeutic agents. Herein, we summarize the diverse biomedical applications of CAs including in vitro diagnosis (biosensing), in vivo diagnosis (bioimaging), and therapy.

中文翻译：

杯芳烃的生物医学应用：最新进展和观点

Calixarenes（CA）代表第三代超分子宿主，也是研究最广泛的大环支架之一，由于其易于修饰，提供（几乎）无限的结构和应用可能性，从而使人们可以建立大型分子库作为材料生物医学应用的基础。而且，CA及其衍生物参与各种非共价相互作用以方便识别包括生物活性分子的客人，并且也是制造超分子体系结构的重要组成部分。考虑到它们的分子识别和自组装特性，CA被广泛应用于生物传感，生物成像和药物/基因传递。另外，一些CA衍生物表现出生物活性，因此可以用作新的治疗剂。在这里

更新日期：2020-01-21

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