An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management.,Angewandte Chemie International Edition

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An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-01-20 , DOI: 10.1002/anie.201912182
Fangfang Cao _{1,

2} , Lu Zhang ₁ , Yawen You _{1,

2} , Lirong Zheng ₃ , Jinsong Ren ₁ , Xiaogang Qu ₁

Affiliation

Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen species (RONS), causes high morbidity and mortality. Despite progress made with nanozymes, efficient antioxidant therapy to eliminate these RONS remains challenging, owing largely to the specificity and low activity of exploited nanozymes. Herein, an enzyme-mimicking single-atom catalyst, Co/PMCS, features atomically dispersed coordinatively unsaturated active Co-porphyrin centers, which can rapidly obliterate multiple RONS to alleviate sepsis. Co/PMCS can eliminate O2 .- and H2 O2 by mimicking superoxide dismutase, catalase, and glutathione peroxidase, while removing . OH via the oxidative-reduction cycle, with markedly higher activity than nanozymes. It can also scavenge . NO through formation of a nitrosyl-metal complex. Eventually, it can reduce proinflammatory cytokine levels, protect organs from damage, and confer a distinct survival advantage to the infected sepsis mice.

中文翻译：

一种模拟酶的单原子催化剂，可作为败血症管理的高效多反应性氧和氮物种清除剂。

败血症的特征在于多种活性氧和氮（RONS）的产生不充分，导致高发病率和死亡率。尽管纳米酶取得了进步，但是有效的抗氧化剂疗法来消除这些RONS仍然具有挑战性，这主要是由于所开发的纳米酶的特异性和低活性。在本文中，模仿酶的单原子催化剂Co / PMCS具有原子分散的配位不饱和活性钴卟啉中心，可快速消除多个RONS以减轻败血症。Co / PMCS可以通过模拟超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶，同时去除O2和H2 O2。OH通过氧化还原循环，其活性明显高于纳米酶。它也可以清除。通过形成亚硝酰基-金属络合物而不会产生NO。最终，

更新日期：2020-02-14

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