Natural products with a bridgehead double bond, such as taxol and CP molecules, have long attracted considerable attention from chemists because of their promising bioactivity and structural complexity, with the high ring-strain energy in the ring systems representing a formidable synthetic challenge. Herein, strategies for the total synthesis of such complex natural products are reviewed for the first time by using 26 representative studies. Methods for constructing the bridged ring system and bridgehead double bond have been emphasized, including syntheses of the same natural product by different research groups using different strategies, to showcase the diversity of thought and creativity in this area. The total synthesis of these natural products not only provides precious bioactive substances and promising candidates for drug discovery but also has stimulated incredible advances in the development of new strategies and synthetic methods.

具有桥头双键的天然产物，如紫杉醇和CP分子，由于其有希望的生物活性和结构复杂性，长期以来一直引起化学家的广泛关注，环系统中高的环应变能代表了巨大的合成挑战。在本文中，首次使用26项代表性研究综述了此类复杂天然产物的全合成策略。强调了构建桥环系统和桥头双键的方法，包括不同研究小组使用不同策略合成同一天然产物的方法，以展示该领域思想和创造力的多样性。