Streptovertimycins A-H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain.,The Journal of Antibiotics

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Streptovertimycins A-H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2020-01-17 , DOI: 10.1038/s41429-020-0277-6
Li Yang _{1,

2} , Xiaoxia Li _{1,

2} , Ping Wu _{1,

3} , Jinghua Xue _{1,

3} , Liangxiong Xu _{1,

4} , Hanxiang Li _{1,

3} , Xiaoyi Wei _{1,

3}

Affiliation

Eight new fasamycin-type polyketides, streptovertimycins A-H (1-8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1-8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group. They exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values in the range of 0.63-5.0 μg/ml. The activity profile provided new insights into the structure-activity relationships of fasamycin-type antibiotics.

中文翻译：

Streptovertimycins AH，一种新的法沙霉素型抗生素，由土壤衍生的莫鲁链霉菌菌株生产。

从小麦籽粒上种植的土壤链霉菌链霉菌SC1169中分离出八个新的法沙霉素型聚酮化合物，链霉亲和素AH（1-8）。通过广泛的光谱分析和ECD光谱的理论计算，确定了它们的结构。化合物1-8具有以15-O-甲基为特征的法沙霉素型五环结构。它们表现出对耐甲氧西林的金黄色葡萄球菌（MRSA）和耐万古霉素的粪便肠球菌（VRE）的有效活性，MIC值为0.63-5.0μg/ ml。活性概况为法沙霉素型抗生素的构效关系提供了新的见解。

更新日期：2020-01-17

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