Ion Mobility Separation Using a Dual-LIT Miniature Mass Spectrometer.,Analytical Chemistry

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Ion Mobility Separation Using a Dual-LIT Miniature Mass Spectrometer.
Analytical Chemistry ( IF 6.7 ) Pub Date : 2020-01-23 , DOI: 10.1021/acs.analchem.9b04271
Jingjin Fan ₁ , Penglong Lian ₁ , Ming Li ₂ , Xinwei Liu ₁ , Xiaoyu Zhou ₁ , Zheng Ouyang ₁

Affiliation

Ion mobility (IM) has been increasingly used in combination with mass spectrometry (MS) for chemical and biological analysis. While implementation of IM with MS usually requires complex instrumentation with delicate controls, in this study we explored the potential of performing IM separation using dual-linear ion traps (LITs) in a miniature mass spectrometer, which was originally developed for performing comprehensive MS/MS scan functions with a simple instrumentation configuration. The IM separation was achieved by ion transfer between the LITs with dynamic gas flow. Its performance was characterized for analysis of a broad range of chemical and biological compounds including small organic compounds such as trisaccharides, raffinose, cellotriose, and melezitose, as well as protein conformers. The demonstrated technique serves as another example of developing powerful hybrid instrument functions with simple configurations and miniaturized sizes.

中文翻译：

使用Dual-LIT微型质谱仪进行离子淌度分离。

离子淌度（IM）已越来越多地与质谱（MS）结合用于化学和生物学分析。虽然使用MS实施IM通常需要复杂的仪器和精细的控制，但在本研究中，我们探索了在微型质谱仪中使用双线性离子阱（LIT）进行IM分离的潜力，该质谱仪最初是为执行综合MS / MS而开发的具有简单的仪器配置的扫描功能。IM分离是通过动态气流在LIT之间进行离子转移来实现的。其性能可用于分析各种化学和生物化合物，包括小型有机化合物，例如三糖，棉子糖，纤维三糖和松三糖，以及蛋白质构象异构体。

更新日期：2020-01-23

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