Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine.,ChemBioChem

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Identification of Human IDO1 Enzyme Activity by Using Genetically Encoded Nitrotyrosine.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-01-15 , DOI: 10.1002/cbic.201900735
Zhaopeng Zheng _{1,

2,

3} , Xuzhen Guo _{3,

4} , Minling Yu ₃ , Xiaoyan Wang ₃ , Hongguang Lu ₁ , Fahui Li ₃ , Jiangyun Wang _{3,

4}

Affiliation

Site exploration : By genetically encoding 3‐nitro‐l ‐tyrosine (NT) into the tyrosine nitration sites of human indoleamine 2,3‐dioxygenase 1 (IDO1), it is revealed that the nitration sites have different effects on the structure and enzyme activity of IDO1.