由卵转铁蛋白原纤维和黄原胶组装而成的水凝胶，作为二氢杨梅素递送载体。,Food & Function

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由卵转铁蛋白原纤维和黄原胶组装而成的水凝胶，作为二氢杨梅素递送载体。
Food & Function ( IF 5.1 ) Pub Date : 2020-01-27 , DOI: 10.1039/c9fo02564b
Zihao Wei ₁ , Yongsheng Chen , Wahyu Wijaya , Yujia Cheng , Jie Xiao , Qingrong Huang

Affiliation

本研究旨在组装蛋白质原纤维-多糖水凝胶作为保健品的运输工具。浊度滴定证实卵转铁蛋白（OVT）原纤维与黄原胶（XG）之间确实发生了络合，静电相互作用是OVT原纤维与XG络合的主要驱动力。优化pH和酸化剂后，可以通过使用葡萄糖酸δ-内酯将pH值调节至4.0来制备稳定的OVT原纤维-XG水凝胶。为了更好地了解OVT原纤维XG凝胶的理化特性，还对XG凝胶进行了表征。扫描电子显微镜表明，OVT原纤维-XG凝胶比XG凝胶具有更致密的网络。流变学测量表明，OVT原纤维-XG凝胶比XG凝胶具有更高的凝胶强度和粘度。OVT原纤维-XG凝胶和XG凝胶可用作二氢杨梅素（DMY）传递载体，具有较高的DMY载量（2 mg mL-1）。使用体外胃肠消化模型研究了DMY的释放。胃肠消化后，所有的DMY都从OVT原纤维XG凝胶中释放出来，胃肠消化后，只有41.7％的DMY从XG凝胶中释放出来，这表明OVT原纤维-XG凝胶在DMY输送中更有效。OMY原纤维-XG凝胶和XG凝胶均通过非菲克转运机制释放了DMY。这项研究的结果可以为蛋白质原纤维-多糖水凝胶的组装和水凝胶作为营养输送工具的合理设计提供新的见解。胃肠消化后，所有的DMY都从OVT原纤维XG凝胶中释放出来，胃肠消化后，只有41.7％的DMY从XG凝胶中释放出来，这表明OVT原纤维-XG凝胶在DMY输送中更有效。OMY原纤维-XG凝胶和XG凝胶均通过非菲克转运机制释放了DMY。这项研究的结果可以为蛋白质原纤维-多糖水凝胶的组装和水凝胶作为营养输送工具的合理设计提供新的见解。胃肠消化后，所有的DMY都从OVT原纤维XG凝胶中释放出来，胃肠消化后，只有41.7％的DMY从XG凝胶中释放出来，这表明OVT原纤维-XG凝胶在DMY输送中更有效。OMY原纤维-XG凝胶和XG凝胶均通过非菲克转运机制释放了DMY。这项研究的结果可以为蛋白质原纤维-多糖水凝胶的组装和水凝胶作为营养输送工具的合理设计提供新的见解。

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Hydrogels assembled from ovotransferrin fibrils and xanthan gum as dihydromyricetin delivery vehicles.

The present study aimed to assemble protein fibril-polysaccharide hydrogels as nutraceutical delivery vehicles. Turbidity titrations confirmed that complexations between ovotransferrin (OVT) fibrils and xanthan gum (XG) indeed occurred, and electrostatic interaction was the major driving force of OVT fibril-XG complexation. After optimization of the pH and acidifier, stable OVT fibril-XG hydrogels could be fabricated by adjusting the pH to 4.0 with glucono delta-lactone. To better understand the physicochemical properties of OVT fibril-XG gel, characterization of XG gel was also conducted. Scanning electron microscopy indicated that OVT fibril-XG gel had a denser network than XG gel. Rheological measurements revealed that OVT fibril-XG gel had higher gel strength and viscosity than XG gel. OVT fibril-XG gel and XG gel could be used as dihydromyricetin (DMY) delivery vehicles with a higher DMY loading (2 mg mL-1). DMY release was investigated using an in vitro gastrointestinal digestion model. All DMY was released from OVT fibril-XG gel after gastrointestinal digestion, and only 41.7% of DMY was released from XG gel after gastrointestinal digestion, indicating that OVT fibril-XG gel was more efficient in DMY delivery. DMY was released via a non-Fickian transport mechanism in both OVT fibril-XG gel and XG gel. The results of this study could provide new insight into the assembly of protein fibril-polysaccharide hydrogels and rational design of hydrogels as nutraceutical delivery vehicles.

更新日期：2020-02-26

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