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Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity.
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2020-01-13 , DOI: 10.1038/s41584-019-0351-2 Frauke Förger 1 , Peter M Villiger 1
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2020-01-13 , DOI: 10.1038/s41584-019-0351-2 Frauke Förger 1 , Peter M Villiger 1
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During pregnancy, the fetus that grows within the maternal uterus is not rejected by the maternal immune system. To enable both tolerance towards the fetus and defence against pathogens, modifications of the maternal immune system occur during gestation. These modifications are able to bring about a natural improvement in disease activity of some autoimmune diseases, such as rheumatoid arthritis (RA). Various mechanisms of the immune system contribute to the phenomenon of pregnancy-related improvement of RA, and the cessation of these immunomodulatory mechanisms after delivery correlates with postpartum disease flare. HLA disparity between mother and fetus, glycosylation of IgG, immunoregulatory pathways, and alterations in innate and adaptive immune cells and their cytokines have important roles in pregnancy and in pregnancy-related amelioration of RA.
中文翻译：
怀孕期间调节类风湿性关节炎疾病活动的免疫适应。
在怀孕期间，在母体子宫内生长的胎儿不会被母体免疫系统排斥。为了既能耐受胎儿又能防御病原体，在妊娠期间会发生母体免疫系统的改变。这些修饰能够自然改善某些自身免疫性疾病的疾病活动，例如类风湿性关节炎 (RA)。免疫系统的各种机制促成了妊娠相关的 RA 改善现象，分娩后这些免疫调节机制的停止与产后疾病发作相关。母亲和胎儿之间的 HLA 差异、IgG 的糖基化、免疫调节途径、
更新日期：2020-01-14
中文翻译：
怀孕期间调节类风湿性关节炎疾病活动的免疫适应。
在怀孕期间，在母体子宫内生长的胎儿不会被母体免疫系统排斥。为了既能耐受胎儿又能防御病原体，在妊娠期间会发生母体免疫系统的改变。这些修饰能够自然改善某些自身免疫性疾病的疾病活动，例如类风湿性关节炎 (RA)。免疫系统的各种机制促成了妊娠相关的 RA 改善现象，分娩后这些免疫调节机制的停止与产后疾病发作相关。母亲和胎儿之间的 HLA 差异、IgG 的糖基化、免疫调节途径、
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