Intratumor heterogeneity reflects clinical disease course,Nature Cancer

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Intratumor heterogeneity reflects clinical disease course
Nature Cancer ( IF 23.5 ) Pub Date : 2020-01-13 , DOI: 10.1038/s43018-019-0002-1
Christine A Iacobuzio-Donahue ₁ , Kevin Litchfield _{2,

3} , Charles Swanton _{2,

3}

Affiliation

Intratumoral genetic heterogeneity of driver somatic mutations is present in a variety of tumor types, yet the extent of heterogeneity is variable. We propose that this variation is a reflection of the inherent biology of a given tumor type, representing the pace of metastatic dissemination and hence clinical disease course.

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