A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry,Organic Process Research & Development

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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-01-10 , DOI: 10.1021/acs.oprd.9b00524
Marcus Baumann ₁ , Thomas S. Moody _{2,

3} , Megan Smyth ₂ , Scott Wharry ₂

Affiliation

Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and critically, the ability to perform chemistry that is difficult or impossible to do in batch mode. Globally, significant efforts have been made to develop the manufacturing flexibility and robustness of processes used to produce chemicals in a continuous way, yet despite these scientific developments, a major challenge for industry is the established application of flow technology to commercially relevant examples. The identification of opportunities to apply flow solutions to current processes is also critical to the success of this new technology for pharmaceutical and fine chemical companies. This review highlights industrial hurdles and the importance of education and showcases recent (2018–2019) and relevant industrial examples where utilization of flow technology has been successfully performed.

中文翻译：

制药行业连续流化学的前景

连续流制造是一个创新的技术平台，在制药行业中正在获得发展。连续流的主要优点包括更快，更安全的反应，这可以使环境更友好，占地面积更小，产品质量更高，并且至关重要的是，能够执行难以或不可能以批处理模式进行的化学反应。在全球范围内，已经做出了巨大的努力来连续地开发用于生产化学品的工艺的制造灵活性和耐用性，然而尽管有这些科学发展，但是工业上的主要挑战是将流技术应用于商业上相关的实例。识别将流动解决方案应用于当前流程的机会对于制药和精细化工公司这项新技术的成功至关重要。这篇综述突出了工业障碍和教育的重要性，并展示了成功实施流动技术的近期（2018-2019年）和相关工业实例。

更新日期：2020-01-10

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