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A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics.
Developmental Cell ( IF 10.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.devcel.2019.12.006 Ghislaine Lioux 1 , Xiaolei Liu 2 , Susana Temiño 1 , Michael Oxendine 2 , Estefanía Ayala 3 , Sagrario Ortega 3 , Robert G Kelly 4 , Guillermo Oliver 2 , Miguel Torres 1
Developmental Cell ( IF 10.7 ) Pub Date : 2020-01-09 , DOI: 10.1016/j.devcel.2019.12.006 Ghislaine Lioux 1 , Xiaolei Liu 2 , Susana Temiño 1 , Michael Oxendine 2 , Estefanía Ayala 3 , Sagrario Ortega 3 , Robert G Kelly 4 , Guillermo Oliver 2 , Miguel Torres 1
Affiliation
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The mammalian heart contains multiple cell types that appear progressively during embryonic development. Advance in determining cardiac lineage diversification has often been limited by the unreliability of genetic tracers. Here we combine clonal analysis, genetic lineage tracing, tissue transplantation, and mutant characterization to investigate the lineage relationships between epicardium, arterial mesothelial cells (AMCs), and the coronary vasculature. We report a contribution of the second heart field (SHF) to a vasculogenic niche composed of AMCs and sub-mesothelial cells at the base of the pulmonary artery. Sub-mesothelial cells from this niche differentiate into lymphatic endothelial cells and, in close association with AMC-derived cells, contribute to and are essential for the development of ventral cardiac lymphatics. In addition, regionalized epicardial/mesothelial retinoic acid signaling regulates lymphangiogenesis, contributing to the niche properties. These results uncover a SHF vasculogenic contribution to coronary lymphatic development through a local niche at the base of the great arteries.
中文翻译：
第二个心脏领域衍生的血管生成利基贡献给心脏淋巴瘤。
哺乳动物的心脏包含在胚胎发育过程中逐渐出现的多种细胞类型。遗传示踪剂的不可靠性常常限制了确定心脏谱系多样化的进展。在这里，我们结合克隆分析，遗传谱系追踪，组织移植和突变体表征来研究心外膜，动脉间皮细胞（AMC）和冠状血管之间的谱系关系。我们报告第二心脏字段（SHF）对由AMCs和肺动脉基底部的间皮细胞组成的血管生成利基的贡献。来自这一小生境的间皮下细胞分化为淋巴管内皮细胞，并且与AMC衍生的细胞密切相关，对腹侧心脏淋巴管的发育有贡献，并对其至关重要。此外，区域性心外膜/间皮视黄酸信号传导调节淋巴管生成，有助于利基特性。这些结果揭示了SHF血管生成通过大动脉根部的局部利基对冠状淋巴管发育的贡献。
更新日期：2020-01-09
中文翻译：
第二个心脏领域衍生的血管生成利基贡献给心脏淋巴瘤。
哺乳动物的心脏包含在胚胎发育过程中逐渐出现的多种细胞类型。遗传示踪剂的不可靠性常常限制了确定心脏谱系多样化的进展。在这里，我们结合克隆分析，遗传谱系追踪，组织移植和突变体表征来研究心外膜，动脉间皮细胞（AMC）和冠状血管之间的谱系关系。我们报告第二心脏字段（SHF）对由AMCs和肺动脉基底部的间皮细胞组成的血管生成利基的贡献。来自这一小生境的间皮下细胞分化为淋巴管内皮细胞，并且与AMC衍生的细胞密切相关，对腹侧心脏淋巴管的发育有贡献，并对其至关重要。此外，区域性心外膜/间皮视黄酸信号传导调节淋巴管生成，有助于利基特性。这些结果揭示了SHF血管生成通过大动脉根部的局部利基对冠状淋巴管发育的贡献。
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