Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes severe kyphosis and a growth defect with decreased chondrocyte proliferation, accelerated hypertrophic differentiation and cell death with reduced Hif1a expression. Eed deficiency also causes induction of multiple signalling pathways in chondrocytes. Wnt signalling overactivation is responsible for the accelerated hypertrophic differentiation and kyphosis, whereas the overactivation of TGF-β signalling is responsible for the reduced proliferation and growth defect. Thus, our study demonstrates that PRC2 has an important regulatory role in lineage-committed tissue cells by suppressing overactivation of multiple signalling pathways.

中文翻译：

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聚梳抑制复合物2通过抑制Wnt和TGF-β信号传导来调节骨骼生长。

聚梳抑制复合物2（PRC2）通过抑制调节细胞分化和组织发育的基因来控制干细胞的维持和谱系确定。但是，PRC2在沿袭承诺的体细胞中的作用大多是未知的。在这里，我们显示软骨细胞中的Eed缺乏会导致严重的后凸畸形，以及软骨细胞增殖减少，肥大分化加速和Hif1a表达降低的细胞死亡所致的生长缺陷。杂草缺乏还引起软骨细胞中多种信号通路的诱导。Wnt信号过度激活导致肥大性分化和后凸畸形加速，而TGF-β信号过度激活导致增殖和生长缺陷减少。因此，