Secondary metabolites (SMs) of medicinal plants are the material basis of their clinically curative effects. They are also important indicators for evaluating the quality of medicinal materials. However, the synthesis and accumulation of SMs are very complex, which are affected by many factors including internal developmental genetic circuits (regulated gene, enzyme) and by external environment factors (light, temperature, water, salinity, etc.). Currently, lots of literatures focused on the effect of environmental factors on the synthesis and accumulation of SMs of medicinal plants, the effect of the developmental growth and genetic factors on the synthesis and accumulation of SMs still lack systematic classification and summary. Here, we have given the review base on our previous works on the morphological development of medicinal plants and their secondary metabolites, and systematically outlined the literature reports how different environmental factors affected the synthesis and accumulation of SMs. The results of our reviews can know how developmental and environmental factors qualitatively and quantitatively influence SMs of medicinal plants and how these can be integrated as tools to quality control, as well as on the improvement of clinical curative effects by altering their genomes, and/or growth conditions.

中文翻译：

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发育和环境因素对药用植物次生代谢产物的影响。

药用植物的次生代谢物（SMs）是其临床疗效的物质基础。它们也是评价药材质量的重要指标。然而，SM的合成和积累非常复杂，受许多因素的影响，包括内部发育遗传回路（调控基因，酶）和外部环境因素（光照，温度，水，盐度等）。目前，许多文献集中在环境因素对药用植物SM合成和积累的影响上，发育发育和遗传因素对SM合成和积累的影响仍缺乏系统的分类和总结。这里，我们根据以前关于药用植物及其次生代谢产物的形态学发展所做的工作进行了综述，并系统地概述了有关不同环境因素如何影响SM合成和积累的文献报道。我们的审查结果可以知道发育和环境因素如何定性和定量地影响药用植物的SM，以及如何将它们整合为质量控制的工具，以及如何通过改变其基因组和/或改善临床疗效生长条件。