Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator.,Cell Death & Disease

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Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator.
Cell Death & Disease ( IF 8.1 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41419-019-2205-x
Nikolaos Charmpilas _{1,

2} , Christoph Ruckenstuhl ₃ , Valentina Sica _{4,

5,

6} , Sabrina Büttner _{3,

7} , Lukas Habernig ₇ , Silvia Dichtinger ₃ , Frank Madeo _{3,

8} , Nektarios Tavernarakis _{1,

9} , José M Bravo-San Pedro _{4,

5,

6} , Guido Kroemer _{4,

5,

6,

10,

11,

12}

Affiliation

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.
Department of Biology, University of Crete, 70013, Heraklion, Crete, Greece.
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Humboldtstrasse 50, 8010, Graz, Austria.
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Inserm U1138, Centre de Recherche des Cordeliers, Sorbonne Universite, Universite de Paris, 15-rue de l'ecole de medecine, 75006, Paris, France.
Team "Metabolism, Cancer & Immunity", equipe 11 labellisee par la Ligue contre le Cancer, Paris, France.
Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm, Sweden.
BioTechMed Graz, Graz, Austria.
Department of Basic Sciences, Faculty of Medicine, University of Crete, 71110, Heraklion, Crete, Greece.
Pole de Biologie, Hopital Europeen Georges Pompidou, AP-HP, Paris, France.
Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China.
Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

Recently, we reported that, in mice, hunger causes the autophagy-dependent release of a protein called "acyl-CoA-binding protein" or "diazepam binding inhibitor" (ACBP/DBI) from cells, resulting in an increase in plasma ACBP concentrations. Administration of extra ACBP is orexigenic and obesogenic, while its neutralization is anorexigenic in mice, suggesting that ACBP is a major stimulator of appetite and lipo-anabolism. Accordingly, obese persons have higher circulating ACBP levels than lean individuals, and anorexia nervosa is associated with subnormal ACBP plasma concentrations. Here, we investigated whether ACBP might play a phylogenetically conserved role in appetite stimulation. We found that extracellular ACBP favors sporulation in Saccharomyces cerevisiae, knowing that sporulation is a strategy for yeast to seek new food sources. Moreover, in the nematode Caenorhabditis elegans, ACBP increased the ingestion of bacteria as well as the frequency pharyngeal pumping. These observations indicate that ACBP has a phylogenetically ancient role as a 'hunger factor' that favors food intake.

中文翻译：

酰基辅酶A结合蛋白（ACBP）：系统发育上保守的食欲刺激剂。

最近，我们报道，在小鼠中，饥饿导致细胞自噬依赖性释放一种称为“酰基辅酶A结合蛋白”或“地西泮结合抑制剂”（ACBP/DBI）的蛋白质，导致血浆ACBP浓度增加。给予额外的 ACBP 可以促进食欲和肥胖，而中和它则可以抑制小鼠的食欲，这表明 ACBP 是食欲和脂肪合成代谢的主要刺激剂。因此，肥胖者的循环 ACBP 水平高于瘦人，神经性厌食症与低于正常的 ACBP 血浆浓度有关。在这里，我们研究了 ACBP 是否可能在食欲刺激中发挥系统发育保守的作用。我们发现细胞外 ACBP 有利于酿酒酵母中的孢子形成，因为我们知道孢子形成是酵母寻找新食物来源的一种策略。此外，在线虫秀丽隐杆线虫中，ACBP 增加了细菌的摄入量以及咽部泵送的频率。这些观察结果表明，ACBP 作为一种有利于食物摄入的“饥饿因素”，在系统发育上具有古老的作用。

更新日期：2020-01-06

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