"Armor-Plating" Enzymes with Metal-Organic Frameworks (MOFs).,Angewandte Chemie International Edition

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"Armor-Plating" Enzymes with Metal-Organic Frameworks (MOFs).
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-01-03 , DOI: 10.1002/anie.201916474
Siming Huang _{1,

2} , Xiaoxue Kou ₂ , Jun Shen ₁ , Guosheng Chen ₂ , Gangfeng Ouyang _{2,

3}

Affiliation

Cell-free enzymatic catalysis (CFEC) is an emerging biotechnology that enable the biological transformations in complex natural networks to be imitated. This biomimetic approach allows industrial products such as biofuels and biochemical to be manufactured in a green manner. Nevertheless, the main challenge in CFEC is the poor stability, which restricts the effectiveness and lifetime of enzymes in sophisticated applications. Immobilization of the enzymes within solid carriers is considered an efficient strategy for addressing these obstacles. Specifically, putting an "armor-like" porous metal-organic framework (MOF) exoskeleton tightly around the enzymes not only shields the enzymes against external stimulus, but also allows the selective transport of guests through the accessible porous network. Herein we present the concept of this biotechnology of MOF-entrapped enzymes and its cutting-edge applications.

中文翻译：

具有金属有机框架（MOF）的“装甲”酶。

无细胞酶催化（CFEC）是一种新兴的生物技术，可以模拟复杂自然网络中的生物转化。这种仿生方法允许以绿色方式生产工业产品，例如生物燃料和生化产品。然而，CFEC的主要挑战是稳定性差，这限制了复杂应用中酶的有效性和寿命。将酶固定在固体载体内被认为是解决这些障碍的有效策略。具体而言，将“铠甲状”多孔金属有机骨架（MOF）外骨骼紧紧置于酶周围，不仅可以保护酶免受外部刺激，而且还可以通过可访问的多孔网络选择性地运输客人。

更新日期：2020-01-03

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