Characterization of the structure and diffusion behavior of calcium alginate gel beads,Journal of Applied Polymer Science

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Characterization of the structure and diffusion behavior of calcium alginate gel beads
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-01-03 , DOI: 10.1002/app.48923
Minghui Hu ₁ , Guoshuang Zheng ₁ , Dewei Zhao _{1,

2} , Weiting Yu _{1,

3}

Affiliation

A simple and novel method using gel shrinkage to indirectly characterize the structure of calcium alginate gel (CAG) beads during the calcium alginate gelation process was presented in this study. The effect of preparation process parameters (gelling cations, bead diameter, and alginate M_w and concentration) on the structure of the CAG bead formation process was thoroughly investigated. It was found that (a) the concentration of the Na⁺ and Ca²⁺ ion in gel bath was found to be the determining factor in the gel structure formation process by regulating the dissociation of alginate and the complexation of the calcium; (b) Na⁺ acts as a competitor with calcium and a screen in the electrostatic repulsion; (c) the effect of beads size below 700 μm on the structure of CAG beads can be neglected; and (d) the sodium alginate concentration has no significant effect on the gel formation process. Furthermore, the diffusion of bovine serum albumin (BSA) was controlled by the density of CAG bead. Consequently, a faster diffusion rate of BSA within the looser structure of beads can be observed. These results are keys to understanding the behavior and performance of beads in their utilization medium. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48923.

中文翻译：

海藻酸钙凝胶珠的结构和扩散行为

在这项研究中提出了一种简单新颖的方法，利用凝胶收缩间接表征藻酸钙胶凝过程中藻酸钙凝胶（CAG）珠的结构。彻底研究了制备工艺参数（凝胶阳离子，珠直径，藻酸盐M _w和浓度）对CAG珠形成工艺结构的影响。发现（a）通过调节藻酸盐的解离和钙的络合，发现凝胶浴中Na ⁺和Ca ²⁺离子的浓度是决定凝胶结构形成过程的决定因素；（b）钠⁺充当钙的竞争者并屏蔽静电排斥；（c）可以忽略尺寸小于700μm的珠子对CAG珠子结构的影响; （d）藻酸钠的浓度对凝胶形成过程没有显着影响。此外，牛血清白蛋白（BSA）的扩散受CAG珠的密度控制。因此，可以观察到BSA在珠的较松散结构内的更快扩散速率。这些结果是了解珠子在其利用介质中的行为和性能的关键。©2020 Wiley Periodicals，Inc. J.Appl。Polym。科学 2020，137，48923。

更新日期：2020-01-03

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