Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery.,Angewandte Chemie International Edition

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Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-02-28 , DOI: 10.1002/anie.201915521
Zacharias Thiel _{1,

2} , Jade Nguyen _{1,

2} , Pablo Rivera-Fuentes ₁

Affiliation

Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super-resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.

中文翻译：

用于成像和药物输送的小分子基因编码激活剂。

化学生物学家已经开发了许多基于基因编码大分子和小型合成化合物的工具。这两种不同的方法非常有用，但它们也有固有的局限性。在这篇迷你评论中，我们重点介绍了结合这两个概念来解决化学生物学中具有挑战性问题的策略示例。我们讨论成像（重点是超分辨技术）以及探针和药物输送中的应用。我们提出了该领域的未来方向，希望激励化学生物学家开发合成和基因编码探针的新组合。

更新日期：2020-02-28

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