Abstract：Throughout the last decade, extensive efforts have been devoted to developing a percutaneous catheter ablation and implantable cardioverter-defibrillator technique for patients suffering from ventricular arrhythmia. Antiarrhythmic drug efficacy for preventing arrhythmias remains disappointing because of adverse cardiovascular effects. Allocryptopine is an isoquinoline alkaloid widely present in medicinal herbs. Studies have indicated that allocryptopine exhibits potential anti-arrhythmic actions in various animal models. The potential therapeutic benefit of allocryptopine in arrhythmia diseases is addressed in this study, focusing on multiple ion channel targets and reduced repolarization dispersion. The limitations of allocryptopine research are clear given a lack of parameters regarding toxicology and pharmacokinetics and clinical efficacy in patients with ventricular arrhythmias. Much remains to be revealed about the properties of allocryptopine.

中文翻译：

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Allocryptopine：其性质和抗心律不齐作用的机制综述。

摘要：在过去的十年中，人们为开发用于心律失常的经皮导管消融和植入式心脏复律除颤器技术进行了广泛的努力。由于心律失常，抗心律失常药物预防心律不齐的功效仍然令人失望。隐氨氯地平是广泛存在于草药中的异喹啉生物碱。研究表明，allocryptopine在各种动物模型中均表现出潜在的抗心律不齐作用。该研究探讨了卡洛平在心律不齐疾病中的潜在治疗益处，重点在于多个离子通道靶点和降低的复极分散度。由于缺乏有关心律失常的毒理学，药代动力学和临床疗效的参数，allocryptopine研究的局限性显而易见。关于allocryptopine的性质还有很多待揭示。