上皮细胞功能障碍对慢性鼻窦炎鼻息肉发病机制的影响,American Journal of Rhinology & Allergy

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上皮细胞功能障碍对慢性鼻窦炎鼻息肉发病机制的影响
American Journal of Rhinology & Allergy ( IF 2.5 ) Pub Date : 2019-08-05 , DOI: 10.1177/1945892419868588
Michael Wynne ₁ , Carl Atkinson _{2,

3} , Rodney J Schlosser ₁ , Jennifer K Mulligan _{1,

4}

Affiliation

背景过去，气道上皮被认为主要是一种惰性物理屏障。我们现在知道上气道上皮在先天性和适应性免疫中都起着关键作用，并且上皮功能障碍与炎症性气道疾病密切相关。慢性鼻窦炎的发病机制知之甚少，但越来越多的证据支持气道上皮在疾病病理生理学中的关键作用。目的本研究的目的是探索我们目前对人类鼻窦上皮细胞 (HSNEC) 功能障碍如何导致慢性鼻窦炎鼻息肉 (CRSwNP) 发病机制的理解，并检查当前和正在开发的疗法如何影响上皮细胞功能。方法使用 PubMed 数据库对以英文发表的有关 CRSwNP 患者上皮细胞功能障碍的论文进行文献综述。搜索使用了以下关键词的组合：鼻窦炎、息肉、上皮、病理生理学、屏障功能、树突细胞、嗜酸性粒细胞、T 细胞、补体、黏液纤毛清除、维生素 D、细胞因子、趋化因子、味觉受体、类固醇、盐水和治疗. 结果 HSNEC 黏液纤毛清除、屏障功能、细胞因子分泌、对树突细胞的影响、对 T 细胞的影响、嗜酸性粒细胞的调节、维生素 D 代谢、补体产生和味觉受体功能在 CRSwNP 患者中发生改变，并有助于其发病机制这种病。当前用于管理 CRSwNP 的疗法可以抵消 HSNEC 功能障碍的影响并缓解该疾病的关键症状。结论 HSNECs是先天免疫和适应性免疫的关键参与者，上皮功能的改变与CRSwNP的发病机制密切相关。我们的审查支持对 CRSwNP 患者 HSNEC 功能改变的进一步调查，并支持开发新的上皮靶向疗法以进行管理。

"点击查看英文标题和摘要"

Contribution of Epithelial Cell Dysfunction to the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps

Background In the past, the airway epithelium was thought to be primarily an inert physical barrier. We now know that the upper airway epithelium plays a critical role in both innate and adaptive immunity, and that epithelial dysfunction is strongly associated with inflammatory airway disease. The pathogenesis of chronic rhinosinusitis is poorly understood, but growing evidence supports a key role for the airway epithelium in the pathophysiology of the disease. Objective The purpose of this study is to explore our current understanding of how dysfunction in human sinonasal epithelial cells (HSNECs) contributes to the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) and to examine how current and developing therapies affect epithelial cell functions. Methods A literature review of papers published in English pertaining to epithelial cell dysfunction in patients with CRSwNP was performed using the PubMed database. The search utilized combinations of the following key words: sinusitis, polyps, epithelium, pathophysiology, barrier function, dendritic cells, eosinophils, T cells, complement, mucociliary clearance, vitamin D, cytokines, chemokines, taste receptors, steroids, saline, and therapy. Results HSNEC mucociliary clearance, barrier function, secretion of cytokines, influence on dendritic cells, influence on T-cells, regulation of eosinophils, vitamin D metabolism, complement production, and taste receptor function are altered in patients with CRSwNP and contribute to the pathogenesis of the disease. Current therapies utilized to manage CRSwNP counteract the effects of HSNEC dysfunction and relieve key symptoms of the disease. Conclusion HSNECs are key players in both innate and adaptive immunity, and altered epithelial functions are closely intertwined with the pathogenesis of CRSwNP. Our review supports further investigation of altered HSNEC function in patients with CRSwNP and supports development of novel epithelial-targeted therapies for its management.

更新日期：2019-08-05

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