OBJECTIVES Patients with moderate dental fluorosis often feel esthetically compromised. Aim of this RCT was to evaluate the objectively and self-assessed masking effect of resin infiltration alone or in combination with in-office bleaching on dental fluorosis in adults. METHODS Twenty-seven patients (9 male, 18 female, 24.81 ± 3.7 yrs) with 410 fluorotic teeth (TF 1-4) were randomly assigned to a treatment (BLI) or control group (NBLI). Patients underwent in-office bleaching (25% H2O2) in the BLI or a placebo bleaching (ACP gel) in the NBLI group followed by resin infiltration after two weeks. Standardized digital photographs were obtained at baseline; after bleaching; before and after resin infiltration and after 1, 3, and 6 months. Color differences (ΔE) between sound and fluorotic areas were calculated and patient satisfaction was evaluated using a VAS (1-10). RESULTS Statistical analysis revealed significant differences in the mean ΔE values 6 months after resin infiltration between the BLI (ΔE = 1.41) and the NBLI group (ΔE = 4.33) (p = 0.024). VAS values increased after resin infiltration (p < 0.05) in both groups. After 3 months patients in the BLI group had higher VAS values than in the NBLI group (p = 0.029). CONCLUSIONS Findings of this study suggest that resin infiltration alone can effectively mask mild to moderate dental fluorosis in young adults. In-office bleaching with 25% H2O2 before resin infiltration provides significantly better masking effects. CLINICAL SIGNIFICANCE Resin infiltration is a safe and efficient treatment option for masking fluorotic opacities. A priori in-office bleaching with 25% H2O2 enhances the masking effect. This controlled clinical trial is registered in the German Clinical Trials Register #DRKS00010465.

中文翻译：

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强力漂白增强了氟牙症的树脂渗透掩盖作用。一项随机临床试验。

目的中度氟中毒患者通常会在美学上感到不适。该RCT的目的是评估树脂渗透单独或与办公室漂白相结合对成人氟牙症的客观和自我评估的掩盖作用。方法将27例410颗含氟牙齿（TF 1-4）的患者（男9例，女18例，24.81±3.7岁）随机分为治疗组（BLI）或对照组（NBLI）。患者在BLI中进行办公室内漂白（25％H2O2）或在NBLI组中进行安慰剂漂白（ACP凝胶），两周后进行树脂浸润。在基线获得标准化的数字照片；漂白后 树脂渗透前后，1、3和6个月后。计算声区和荧光区之间的色差（ΔE），并使用VAS（1-10）评估患者满意度。结果统计分析表明，树脂浸润后6个月，BLI组（ΔE= 1.41）和NBLI组（ΔE= 4.33）之间的平均ΔE值存在显着差异（p = 0.024）。两组树脂渗透后，VAS值均增加（p <0.05）。3个月后，BLI组患者的VAS值高于NBLI组（p = 0.029）。结论这项研究的结果表明，单独的树脂浸润可以有效掩盖年轻人中轻度至中度的氟牙症。在树脂渗透之前用25％H2O2进行办公室内漂白可显着改善掩盖效果。临床意义树脂浸润是掩盖氟不透明的安全有效的治疗方法。预先在办公室用25％H2O2漂白可增强掩盖效果。该对照临床试验已在德国临床试验注册证＃DRKS00010465中注册。