膳食补充剂在帕金森病管理中的作用。,Biomolecules

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膳食补充剂在帕金森病管理中的作用。
Biomolecules ( IF 4.8 ) Pub Date : 2019-07-10 , DOI: 10.3390/biom9070271
Michele Ciulla ₁ , Lisa Marinelli ₁ , Ivana Cacciatore ₁ , Antonio Di Stefano ₁

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在过去的几十年中，食品补充剂或功能性食品的使用显着增加，特别是为了弥补现代生活方式和工业化国家的食品短缺。尽管食品补充剂习惯性地旨在纠正营养缺乏或支持特定的生理功能，但它们通常与常见的药物疗法相结合，以改善患者的健康和/或减轻许多慢性疾病的症状，如心血管疾病、囊性纤维化、癌症、肝脏和胃肠道疾病。近年来，患者的饮食越来越受到重视，富含维生素和抗氧化剂的膳食补充剂和功能性食品的使用在帕金森病（PD）等神经退行性疾病的治疗和预防中发挥着非常重要的作用。与参与疾病发展的一些主要病理生理机制（如氧化应激、自由基形成和神经炎症）相比，天然化合物、植物化学物质、维生素和矿物质可以预防、延迟或减轻 PD 的临床症状。本综述的目的是收集科学证据，支持使用食品补充剂或功能性食品中常见的特定生物分子和生物元素来改善 PD 患者的临床框架。

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Role of Dietary Supplements in the Management of Parkinson's Disease.

The use of food supplements or functional food has significantly increased in the past decades, especially to compensate both the modern lifestyle and the food shortages of the industrialized countries. Despite food supplements are habitually intended to correct nutritional deficiencies or to support specific physiological functions, they are often combined with common drug therapies to improve the patient's health and/or mitigate the symptoms of many chronic diseases such as cardiovascular diseases, cystic fibrosis, cancer, liver and gastrointestinal diseases. In recent years, increased attentions are given to the patient's diet, and the use of food supplements and functional food rich in vitamins and antioxidants plays a very important role in the treatment and prevention of neurodegenerative diseases such as Parkinson's disease (PD). Natural compounds, phytochemicals, vitamins, and minerals can prevent, delay, or alleviate the clinical symptoms of PD in contrast to some of the main physiopathological mechanisms involved in the development of the disease, like oxidative stress, free radical formation, and neuroinflammation. The purpose of this review is to collect scientific evidences which support the use of specific biomolecules and biogenic elements commonly found in food supplements or functional food to improve the clinical framework of patients with PD.

更新日期：2019-11-01

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