Incubation of food craving is an abstinence-dependent increase in responding for reward-paired cues. Incubation of craving was first reported for rats responding for cocaine-paired cues, and later generalized to several drugs of abuse and for food. Incubation of drug and food craving has been reported in clinical studies as well. Incubation of food craving by rats has been reported for standard chow as well as for high fat and sucrose reinforcers. Parametric and other evaluations of the incubation of food craving reveal manipulations that reduce incubation, including environmental enrichment and pharmacological manipulation of dopamine, glutamate, and endogenous opiates. Several brain regions are likely involved in the effect, including mesolimbic terminals and the central nucleus of the amygdala. Further study of the incubation of food craving could facilitate development of treatments for cravings that precede relapse characteristic of drug and food addictions.

中文翻译：

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大鼠食物渴望的孵化：综述。

食物渴望的孵化是对奖励配对线索的反应的禁欲依赖性增加。对可卡因配对线索有反应的大鼠首次报道了渴望的孵化，后来推广到几种滥用药物和食物。在临床研究中也报道了对药物和食物渴望的孵化。据报道，对于标准食物以及高脂肪和蔗糖强化剂，大鼠会产生对食物的渴望。对食物渴望孵化的参数和其他评估揭示了减少孵化的操作，包括环境富集和多巴胺、谷氨酸和内源性阿片类药物的药理学操作。几个大脑区域可能与这种效应有关，包括中脑边缘末梢和杏仁核的中央核。